Publications by authors named "Alice Seris"
Background: Malignant hypertension has not disappeared and remains the most severe form of hypertension. More than 100 years after its description, many points remain unanswered. Mechanisms, definitions, and optimal treatment are still controversial.
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- Porocarcinoma is a malignant sweat gland tumor that can develop from benign poromas, and recent studies have identified specific genetic fusions like PAK1/2/3 in some cases.
- In a study of 12 porocarcinoma patients, most were older males with tumors located on various parts of the body, and some patients developed distant metastases.
- The research indicates that PAK1/2/3 fusions might drive cancer development in porocarcinomas that do not have YAP1 rearrangements, highlighting a potential target for treatment.
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- The study examines the long-term effectiveness of immune checkpoint inhibitor (ICI) rechallenge in patients with advanced melanoma who previously responded to ICI treatment.
- A total of 85 patients participated, with a notable 54% showing a positive response to the rechallenge, including 35% achieving a complete response.
- However, safety concerns emerged, as 27% experienced adverse events, and those who underwent other treatments between ICI courses had lower response rates and shorter progression-free survival.
Recurrent oncogenic drivers have been identified in a variety of sweat gland tumors. Recently, integration of human papillomavirus type 42 (HPV42) has been reported in digital papillary adenocarcinoma (DPA). The main objectives of the present study were (i) to provide an overview of the prevalence of previously identified oncogenic drivers in acral sweat gland tumors and (ii) to genetically characterize tumors in which no recurrent genetic alteration has been identified yet.
View Article and Find Full Text PDFDigital papillary adenocarcinoma (DPA) is a rare sweat gland neoplasm that has exceptionally been reported outside acral locations. Recently, human papillomavirus 42 was identified as the main oncogenic driver of DPA. Herein, we report 5 tumors arising in extra-acral locations predominantly in the female anogenital skin.
View Article and Find Full Text PDFPurpose: To prospectively assess the impact of expert pathological review of skin adnexal carcinoma diagnosis in France.
Methods: From 2014 to 2019, 2573 samples from patients with newly diagnosed or suspected skin adnexal carcinomas were reviewed prospectively by expert pathologists through the national CARADERM (CAncers RAres DERMatologiques) network. Changes in diagnosis between referral and expert review were analysed regarding their potential impact on patient care or prognosis.
We report 21 cases of trichogerminoma harbouring previously undescribed FOXK1::GRHL1/2 or GPS2::GRHL1/2/3 in-frame fusion transcripts. Microscopic examination of a preliminary set of five cases revealed well-delimitated tumours located in the dermis with frequent extension to the subcutaneous tissue. Tumours presented a massive and nodular architecture and consisted of a proliferation of basaloid cells.
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