Publications by authors named "Alice Santopolo"
Article Synopsis
- Myeloproliferative neoplasms (MPN) exhibit abnormal JAK2 signaling, and while JAK2 inhibitors help treat them, the MAPK pathway often compensates and limits their effectiveness.
- The study proposed that targeting both JAK2 and ERK1/2 could improve treatment, showing that ERK1/2 deficiency reduced MPN symptoms and the Jak2V617F clone in models and patient samples.
- Combining JAK2 and ERK1/2 inhibitors demonstrated a significant reduction in cancer cell proliferation and various MPN symptoms, indicating a promising new therapeutic strategy for treating MPN.
