Publications by authors named "Alice N Young"
Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters. Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory interactions on a genomic scale. Here we use Capture Hi-C (CHi-C), an adapted genome conformation assay, to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types.
View Article and Find Full Text PDFMeet the neighbours: tools to dissect nuclear structure and function.
Brief Funct Genomics
January 2011
Article Synopsis
- - The eukaryotic cell nucleus is highly organized, featuring specific subcompartments that create unique environments for certain cellular processes, and the genome is structured to interact with these areas.
- - Many roles of these nuclear subcompartments and their associated genomic regions are still not well understood, leading to questions about how genome organization influences cellular function and vice versa.
- - Recent advancements in methodology allow researchers to investigate the spatial arrangement of the genome, shedding light on the connections between genome structure and function, and helping to identify the roles of various nuclear subcompartments.