Synopsis of recent research by authors named "Alice Muntzer"
- Alice Muntzer's research focuses on enhancing the efficacy of immunotherapy in treating solid tumors, specifically by addressing challenges such as tumor heterogeneity and immunosuppressive microenvironments.
- One significant study investigates the use of T-SIGn tumor reengineering therapy in combination with CAR T cells, demonstrating their synergistic effects in clearing human lung tumor xenografts in NSG mice, highlighting the potential of oncolytic viruses to improve immunotherapy outcomes.
- Another study explores an oncolytic virus modified to express a T-cell engager that targets both cancer cells and immune-suppressive stromal cells, illustrating a dual approach that activates T cells while simultaneously reducing the immunosuppressive tumor microenvironment, thereby improving anti-tumor responses.
