Publications by authors named "Alice Le-Gatt"
Mesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune-mediated diseases. They exert immunoregulatory and tissue-restoring effects. MSC-mediated transfer of mitochondria (MitoT) has been demonstrated to rescue target organs from tissue damage, yet the mechanism remains to be fully resolved.
View Article and Find Full Text PDFArticle Synopsis
- Significant progress has been made in understanding wound healing, but chronic wound treatments are still challenging; mesenchymal stem cells (MSCs) from sources like umbilical cord and adipose tissue show promise for improving healing.
- Menstrual fluid-derived MSCs (MenSCs) present an innovative, non-invasive source and exhibit superior clonogenic and migratory potential, as well as enhanced immunomodulatory functions compared to traditional MSC sources.
- In experiments, MenSCs not only improved wound closure and neovascularization in animal models but also showed higher expression levels of key genes involved in wound repair, indicating their potential as a better therapeutic option for chronic wounds.