Investigating the presentation of uncertainty in an icon array: A randomized trial.

Background: Clinicians are often advised to use pictographs to communicate risk, but whether they offer benefits when communicating risk imprecision (e.g., 65%-79%) is unknown.

Making BRCA1 genetic test reports easier to understand through user-centered design: A randomized trial.

Purpose: Our objective was to apply a user-centered design process to identify phrases, graphics, and ways of communicating numerical risks that could be used to help patients understand their cancer risk and next steps on receiving BRCA1 genetic test results (positive, negative, and variants of uncertain significance).

Methods: The first phase of the study, a user-centered design process, consisted of 4 rounds of interviews (N = 42, including 13 health care professionals and 16 patients having undergone BRCA testing). The second was a randomized, between-participants experimental study of 456 United Kingdom residents that compared the resulting reports to reports used in a United Kingdom national genomic laboratory hub.

Communicating personalized risks from COVID-19: guidelines from an empirical study.

As increasing amounts of data accumulate on the effects of the novel coronavirus SARS-CoV-2 and the risk factors that lead to poor outcomes, it is possible to produce personalized estimates of the risks faced by groups of people with different characteristics. The challenge of how to communicate these then becomes apparent. Based on empirical work (total = 5520, UK) supported by in-person interviews with the public and physicians, we make recommendations on the presentation of such information.

A new record for a massive Porites colony at Ta'u Island, American Samoa.

An exceptionally large, hermatypic colony of Porites sp. has been identified and measured at Ta'u, American Samoa. This coral was measured in November 2019 as part of an effort to catalogue all large (≥ 2 m diameter) Porites colonies around Ta'u.

Conus-level combined dorsal and ventral lumbar rhizotomy for treatment of mixed hypertonia: technical note and complications.

Combined dorsal and ventral rhizotomy is an effective treatment for patients with concurrent spasticity and dystonia, with the preponderance of complaints relating to their lower extremities. This operative approach provides definitive relief of hypertonia and should be considered after less-invasive techniques have been exhausted. Previously, the surgery has been described through an L1-S1 laminoplasty.

Nutrient thresholds to protect water quality and coral reefs.

Establishing nutrient thresholds to protect coral reefs is difficult because water quality is dynamic and shifts with many environmental factors. We examined the contribution of natural and human factors in predicting water quality at the base of 34 streams on a high tropical Pacific island. Mixed regression models revealed that rainfall, sea-surface temperature, and windspeed were fixed factors predicting dissolved inorganic nitrogen (DIN) concentrations at the base of all watersheds.

Target Capture Sequencing Unravels Evolution.

(Rosaceae) comprises more than 500 species with additional commercially cultivated raspberries and blackberries. The most recent (> 100 years old) global taxonomic treatment of the genus defined 12 subgenera; two subgenera were subsequently described and some species were rearranged. Intra- and interspecific ploidy levels and hybridization make phylogenetic estimation of challenging.

Early clinical indicators of developmental outcome in abusive head trauma.

Purpose: The purpose of the study was to determine the developmental prognostic significance of early clinical indicators in abusive head trauma.

Methods: Seventy-one children were diagnosed with abusive head trauma and followed in a post-injury growth and development clinic. A retrospective chart review was completed to gather clinical features at the time of injury, including presence or absence of early post-traumatic seizures, presence or absence of intubation, and presence or absence of pediatric intensive care unit admission.

Angiosperm phylogeny based on matK sequence information.

Plastid matK gene sequences for 374 genera representing all angiosperm orders and 12 genera of gymnosperms were analyzed using parsimony (MP) and Bayesian inference (BI) approaches. Traditionally, slowly evolving genomic regions have been preferred for deep-level phylogenetic inference in angiosperms. The matK gene evolves approximately three times faster than the widely used plastid genes rbcL and atpB.