Synopsis of recent research by authors named "Alice L Kwon"
Alice L Kwon's research primarily focuses on the structural biology of the HIV-1 envelope trimer, investigating how its conformation protects the virus from neutralizing antibodies.
Her studies reveal that specific hydrophobic interactions and conserved residues at the trimer apex are crucial for maintaining the closed, metastable configuration of the envelope spike, which is critical for immune evasion.
Mutations in key amino acids significantly alter HIV-1's susceptibility to neutralization, indicating that these structural elements are potential targets for therapeutic intervention against the virus. *
