Publications by authors named "Alice Kit-Ying Chan"

Article Synopsis
  • This study analyzes the role of polyamines in oral health, particularly among older adults, and their dysregulation linked to inflammatory and cancer conditions.
  • Researchers reviewed literature from 2000 to May 2024, identifying 19 relevant studies out of 2725 publications focused on older adults (65+).
  • Findings indicate increased polyamine levels, like spermidine and putrescine, in those with oral carcinoma, periodontal infections, and halitosis, suggesting these compounds could serve as non-invasive biomarkers for these conditions.
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Background: Increasing studies have shown that poor oral health contributes to the progression of dementia. It is meaningful to find out the role of oral health interventions in maintaining people's cognition levels and delaying the progression of dementia. Thus, we conducted this review to summarize the present evidence on the effect of oral health interventions on the cognition change of people with dementia.

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Article Synopsis
  • The article emphasizes the significance of oral health in promoting healthy aging, which is defined as maintaining functional ability and well-being in later years, according to the World Health Organization.* -
  • Good oral health not only influences physical, cognitive, and psychological health but also supports nutritional intake, thus enhancing the overall quality of life for older adults, their families, and society as a whole.* -
  • It calls for collaboration among policy makers, dental associations, and healthcare professionals to implement reforms aimed at ensuring equitable access to oral health care and preventing oral diseases in older adults.*
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Objective: To assess the clinical evidence for silver diamine fluoride (SDF) to reduce dentine hypersensitivity in adults.

Methods: Two independent researchers searched the English literature in five databases (Scopus, PubMed, Web of Science, EMBASE and the Cochrane Library) up to 15th July 2023 for clinical trials investigating the desensitising effect of professionally applied SDF to manage dentine hypersensitivity in adults aged 18 or above at any follow-up period. The primary outcome was the change in dentine hypersensitivity between baseline and follow-up visits after SDF application regarding any validated pain outcome measures.

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Introduction: Tooth wear is a prevalent dental condition among older adults, leading to pain and adversely affecting aesthetics, functionality, and their overall quality of life. This review aims to update the information on tooth wear in older adults from the past five years and to provide guidance on the clinical management of tooth wear in older adults.

Methods: A literature search was conducted in three electronic databases, Scopus, Pubmed, and Embase, for English publications from January 2019 to December 2023 on clinical studies with participants aged 65 or above on tooth wear.

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Background: Non-institutionalised older adults is the majority of older adults in Hong Kong. The study aimed to examine erosive tooth wear (ETW) and its association with dental conditions and oral hygiene habits among non-institutionalised older adults in Hong Kong.

Methods: This cross-sectional study recruited dentate adults aged 60 or above from nine elderly daycare centres in the five main districts of Hong Kong.

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Introduction: The aim of this systematic review is to provide a clinical update of the current knowledge on COVID-19 and oral mucosal lesions, to analyze the types and prevalence of oral mucosal lesions in patients with COVID-19, and to clarify the potential association between COVID-19 and oral mucosal lesions.

Methods: The literature search was conducted using PubMed, Web of Science, Scopus and the Cochrane Library, as well as literatures via manual searches of the reference lists of included studies. Studies published in English that mentioned oral mucosal lesions in patients with COVID-19 were included, resulting in a total of 31 studies.

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Non-communicable diseases (NCDs), which contribute significantly to global morbidity, are largely preventable through behavioral changes. As with other NCDs, periodontitis is associated with modifiable risk factors such as smoking and stress and is linked to multiple adverse health outcomes through a shared pathway of chronic systemic inflammation. While the health benefits of physical activity have been widely promoted in public health and extensively studied for other systemic conditions, its impact on periodontal health has only recently started to gain attention.

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Diet, nutrition, and oral health are closely linked. Malnutrition is a challenging health concern in older adults that is associated with physical decline affecting their daily activities and quality of life. The aim of this review is to provide an evidence-based summary of the relationship between diet and nutrition and oral health in older adults and its implications.

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Objective: This study aimed to evaluate the desensitizing effect of topically applied 38% silver diamine fluoride (SDF) solution on the exposed root surface of hypersensitive teeth in older adults.

Method: This double-blind randomised clinical trial recruited healthy older adults with dentine hypersensitivity. A trained examiner tested the most hypersensitive tooth root surface with a blast of compressed cold air from a three-in-one syringe.

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The prevalence of oral diseases in the older adult population remains high worldwide and is expected to surge in the coming decade. The World Health Organization (WHO) has listed the oral health of older adults as one of its pivotal concerns. Oral health affects general health, and oral diseases increase mortality and morbidity in older adults.

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Background: Dentine hypersensitivity on an exposed root surface induces pain, affects daily oral hygiene practice, limits dietary choices and negatively affects quality of life. Silver diamine fluoride is marketed in the United States as a desensitising agent, but well-designed clinical trials are limited. This study evaluates the anti-hypersensitivity effect of silver diamine fluoride on hypersensitive teeth due to an exposed root surface in older Chinese adults.

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Objective: To assess the clinical evidence for professionally applied fluoride therapy to prevent and arrest caries in older adults.

Data/sources: Two independent researchers searched the English literature published up to 31st Dec 2021 in five databases (PubMed, Scopus, the Cochrane Library, EMBASE, and Web of Science) for clinical trials with a comparison group on professionally applied fluoride therapy for caries prevention or arrest at older adults aged ≥60 years with any follow-up period. The outcomes were the mean difference in the number of new caries/caries-prevented fraction and caries arrest rate.

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The older adult population is increasing both in number and in proportion worldwide. In Hong Kong, the number of people aged 65 or above is expected to reach 2.5 million in 2039, thus becoming one-third of the population.

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The aim of this systematic review was to provide an update on caries prevalence in older adults aged 60 years or above around the globe. Two independent reviewers performed a systematic literature search of English publications from January 2016 to December 2020 using Pubmed, Scopus, Embase/Ovid and Web of Science. The MeSH terms used were "dental caries", "root caries", "DMF index", "aged" and "aged 80 and over".

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The advancement of medicine has reduced the rate of mortality and older adult population is increasing. Among the 7,700,000,000 world population in 2019, 1 in 11 people were at the age of 65 or more. The population is expected to increase to 1 in 6 people by 2050.

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Objective: This study aimed to investigate the global research interest regarding silver diamine fluoride (SDF) in dentistry using a bibliometric approach.

Methods: A literature search was conducted in the Web of Science Core Collection database to identify studies related to SDF. Bibliometric data from the selected publications were exported and analysed using the Bibliometrix Biblioshiny R-package software.

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Article Synopsis
  • * The study aimed to assess aspirin's effectiveness against Candida biofilms on surgical catheters, testing different concentrations and exposure times.
  • * Results indicated that aspirin effectively eradicated biofilms, with a concentration of 40 mg/mL showing success within 4 hours for one Candida species and within 24 hours for others, suggesting aspirin's potential use in anti-fungal lock therapy.
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