Publications by authors named "Alice Jang"
Article Synopsis
- - The rise in obesity and type 2 diabetes is notably affecting pregnant women, leading to increased use of low-calorie sweeteners (LCSs) to reduce calorie intake while still providing sweetness.
- - Research using a mouse model showed that male offspring from mothers consuming LCSs developed high body fat and glucose intolerance, with significant changes in brain circuits and pancreatic function.
- - A metabolite called phenylacetylglycine (PAG) was found to be elevated in the milk of LCS-fed mothers and their offspring, suggesting it may play a role in the negative metabolic and neurodevelopmental effects observed from maternal LCS consumption.
Sugar-sweetened beverage consumption is a known independent risk factor for nonalcoholic steatohepatitis (NASH). Non-caloric sweeteners (NCS) are food additives providing sweetness without calories and are considered safe and/or not metabolized by the liver. The potential role of newer NCS in the regulation of NASH, however, remain unknown.
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- The rise in obesity and type II diabetes, especially in children, is linked to maternal obesity, which negatively affects offspring's metabolism.
- In a study using mice, researchers found that offspring of obese mothers had issues like glucose intolerance, increased weight, and disrupted hormone signaling related to hunger.
- Treatment with tauroursodeoxycholic acid, which alleviates ER stress, showed promise in reversing some metabolic and developmental problems in these offspring.