Publications by authors named "Alice Hoffsten"
Article Synopsis
- The study focuses on the role of Goblet cells and the marker REG4 in necrotizing enterocolitis (NEC) among preterm infants, comparing biopsies from infants with NEC to those without.
- Results show that REG4 expression was significantly lower in infants with NEC, suggesting a potential link between Goblet cell dysfunction and NEC risk.
- However, the study also indicates that the maturity of the infants may influence REG4 expression, complicating the interpretation of the results.
Unlabelled: Previous studies suggest that Paneth cells are involved in NEC development. Defensin alpha 6 (DEFA6) and guanylate cyclase activator 2A (GUCA2A) are selective protein markers of Paneth cells. The objective was to explore DEFA6 and GUCA2A expression in intestinal tissue samples from newborn infants with and without NEC.
View Article and Find Full Text PDFNecrotizing enterocolitis (NEC) is a fatal disease where current diagnostic tools are insufficient for preventing NEC. Early predictive biomarkers could be beneficial in identifying infants at high risk of developing NEC. To explore early biomarkers for predicting NEC in extremely preterm infants (EPIs).
View Article and Find Full Text PDFArticle Synopsis
- Reliable data on causes of death in preterm infants is crucial for evaluating perinatal care and guidelines.
- In a study analyzing preterm infants (< 37 weeks) who died in a Swedish neonatal unit, autopsy results revealed significant discrepancies between preliminary and confirmed causes of death.
- The research showed that necrotizing enterocolitis (NEC) as a cause of death rose notably in the later study period, and autopsy confirmed or revised the cause of death in about one-third of the cases, emphasizing the importance of autopsy for accurate COD determination.