Publications by authors named "Alice Helena de Souza Paulino"
Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring.
Maíra Schuchter Ferreira Sheila Cristina Potente Dutra Luquetti Poliana Guiomar de Almeida Brasiel Kacia Mateus Alice Helena de Souza Paulino
J Dev Orig Health Dis
April 2022
Article Synopsis
- Soy consumption offers various health benefits, but its phytoestrogen content raises concerns during lactation and pregnancy, prompting a study on its cardiovascular effects on lactating rats and their offspring.
- Lactating rats were divided into groups based on diet (soy protein isolate, soybean, casein), revealing that both soy protein and soybean reduced atherogenic indices (cholesterol ratios) in offspring compared to the control group.
- While the soybean group's offspring showed lower oxidative stress, the soy protein isolate group had negative long-term effects, like increased liver cholesterol and worsened atherogenic indices in adulthood, suggesting caution in soy protein consumption during lactation.
Non-alcoholic fatty liver disease (NAFLD), the most predominant liver disease worldwide, is a progressive condition that encompasses a spectrum of disorders ranging from steatosis to steatohepatitis, and, ultimately, cirrhosis and hepatocellular carcinoma. Although the underlying mechanism is complex and multifactorial, several intracellular events leading to its progression have been identified, including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and altered endoplasmic reticulum (ER) homeostasis. Phenolic compounds, such as those present in açai (Euterpe oleracea Mart.
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