Publications by authors named "Alice Haystead"
Background: Despite an aging population, it remains challenging to reliably differentiate between loss of cognitive function associated with normal aging and cognitive decline associated with pathologic processes. With growing interest in using retinal and optic nerve biomarkers to diagnose neurodegenerative diseases, characterization of the velocity of normal retinal age‐related changes will further our understanding. We evaluated longitudinal microvascular changes in cognitively normal older adults using optical coherence tomography (OCT) and OCT angiography (OCTA).
View Article and Find Full Text PDFBackground: Mild cognitive impairment (MCI) is currently a clinical diagnosis characterized by decline in memory and daily cognitive function from baseline. Exploratory studies using optical coherence tomography angiography have reported alterations in the retinal capillary plexus vessel density and attenuation of the retinal nerve fiber layer, but these results appear to be mixed. We used ultra‐widefield (UWF) imaging to evaluate retinal and choroidal vasculature and structure in individuals with mild cognitive impairment (MCI) compared to controls with normal cognition.
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- Frontotemporal dementia (FTD) is a neurodegenerative disorder affecting brain areas linked to cognition and personality, and this study aimed to explore retinal and choroidal changes in FTD patients compared to cognitively normal individuals using specialized imaging techniques.
- The study involved analyzing various retinal imaging parameters in 19 FTD patients and 48 control participants, using methods like optical coherence tomography (OCT) and OCT angiography (OCTA) to assess differences in retinal tissue and blood flow.
- Results indicated significant reductions in macular perfusion density and vessel density in FTD patients, suggesting that retinal changes could serve as potential biomarkers for early detection of FTD, warranting further research using noninvasive imaging techniques.
To evaluate longitudinal peripapillary changes in cognitively normal older adults using optical coherence tomography (OCT) and OCT angiography (OCTA). Participants older than 50 years with no history of neurodegenerative disease or cognitive impairment were prospectively enrolled. OCT and OCTA images were obtained at the first visit and 2 years later.
View Article and Find Full Text PDFPurpose: To utilize ultrawidefield (UWF) imaging to evaluate retinal and choroidal vasculature and structure in individuals with mild cognitive impairment (MCI) compared with that of controls with normal cognition.
Design: Prospective cross sectional study.
Participants: One hundred thirty-one eyes of 82 MCI patients and 230 eyes of 133 cognitively normal participants from the Eye Multimodal Imaging in Neurodegenerative Disease Study.
Article Synopsis
- The study aimed to analyze changes in retinal and choroidal structures among patients with Huntington's Disease (HD) who possess the mutant huntingtin protein gene (mHtt) compared to healthy individuals.
- It involved a cross-sectional comparison between symptomatic HD patients and cognitively normal controls using advanced imaging techniques to assess various retinal metrics.
- Findings revealed that HD patients had significantly reduced ganglion cell-inner plexiform layer (GCIPL) thickness and smaller foveal avascular zone (FAZ) area, suggesting that retinal changes could serve as biomarkers for neurodegeneration in HD.
To evaluate the retinal and choroidal microvasculature and structure in individuals with dementia with Lewy bodies (DLB) compared with controls with normal cognition using optical coherence tomography (OCT) and OCT angiography (OCTA). An institutional review board-approved cross-sectional comparison of patients with DLB and cognitively normal controls was performed. The Cirrus HD-OCT 5000 with AngioPlex (Carl Zeiss Meditec) was used to obtain OCT and OCTA images.
View Article and Find Full Text PDFPurpose: To train and test convolutional neural networks (CNNs) to automate quality assessment of optical coherence tomography (OCT) and OCT angiography (OCTA) images in patients with neurodegenerative disease.
Methods: Patients with neurodegenerative disease were enrolled in the Duke Eye Multimodal Imaging in Neurodegenerative Disease Study. Image inputs were ganglion cell-inner plexiform layer (GC-IPL) thickness maps and fovea-centered 6-mm × 6-mm OCTA scans of the superficial capillary plexus (SCP).