Publications by authors named "Alice H Y Man"
Article Synopsis
- The study investigates early-onset colorectal cancer (EOCRC) through a new organoid biobank that includes cancer and normal organoids from patients.
- It reveals significant molecular diversity and identifies different transcriptional profiles between fusion and mutant organoids, as well as potential maturation pathways.
- The findings provide valuable genomic insights into EOCRC that enhance understanding and could aid in developing better models for future research.
Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique subtypes are urgently needed for precision medicine development. Here, we have established a primary gastric cancer organoid (GCO) biobank that comprises normal, dysplastic, cancer, and lymph node metastases (n = 63) from 34 patients, including detailed whole-exome and transcriptome analysis.
View Article and Find Full Text PDFObjective: Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI) due to MLH1 promoter methylation (MLH1). We investigate genetic alterations in the serrated polyposis pathway.
Design: We used a combination of exome sequencing and target gene Sanger sequencing to study serrated polyposis families, sporadic serrated polyps and CRCs, with validation by analysis of The Cancer Genome Atlas (TCGA) cohort, followed by organoid-based functional studies.