Publications by authors named "Alice Blaj"
Cancer Discov
November 2023
Article Synopsis
- Previous research highlighted PRMT5 as a target for treating cancers lacking the MTAP gene (MTAP del), but effective small-molecule inhibitors like MRTX1719 were not fully explored until now.
- MRTX1719 specifically inhibits PRMT5 activity in the presence of elevated MTA found in MTAP del cancers, showing significant anti-tumor effects and selective efficacy in cancer cells with MTAP deletions.
- Early clinical trials indicate that MRTX1719 may help patients with various cancers carrying the MTAP deletion, representing a promising treatment option for about 10% of cancer patients with this specific genetic marker.
