Publications by authors named "Alice Anna Daddi"
The adult gastric mucosa is characterised by deep invaginations of the epithelium called glands. These tissue architectural elements are maintained with the contribution of morphogen signals. Morphogens are expressed in specific areas of the tissue, and their diffusion generates gradients in the microenvironment.
View Article and Find Full Text PDFMolecular modelling of the gastric barrier response, from infection to carcinogenesis.
Best Pract Res Clin Gastroenterol
May 2021
The lining of the stomach is a tight monolayer of epithelial cells performing functions in digestion and a protective barrier against gastric acid, toxic metabolites and infectious agents, including Helicobacter pylori. The response of the epithelial barrier to infections underlies gastric pathologies, including gastric cancer. H.
View Article and Find Full Text PDFArticle Synopsis
- The gastrointestinal epithelium maintains balance through the regeneration and differentiation of cells in glands and crypts, which is regulated by the Wnt/β-catenin pathway and various signaling signals.
- Researchers created mucosoid cultures from human stomachs and tested different growth factors to identify how they contribute to the differentiation of specific cell types (foveolar, chief, and parietal cells).
- Findings indicated that epidermal growth factor plays a crucial role in determining cell fate within gastric glands and may contribute to changes seen in precancerous conditions like atrophic gastritis, leading to a better understanding of gastric tissue signaling.