Publications by authors named "Alice A Brandli"
Purpose: Following successful clinical outcomes of the prototype suprachoroidal retinal prosthesis, Bionic Vision Australia has developed an upgraded 44-channel suprachoroidal retinal prosthesis to provide a wider field of view and more phosphenes. The aim was to evaluate the preclinical passive safety characteristics of the upgraded electrode array.
Methods: Ten normal-sighted felines were unilaterally implanted with an array containing platinum electrodes (44 stimulating and 2 returns) on a silicone carrier near the area centralis.
Myo/Nog cells are essential for eye development in the chick embryo and respond to injury in adult tissues. These cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (mAb). In this study, we determined that Myo/Nog cells are present in low numbers in the retina of the mouse eye.
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- Researchers used synchrotron FT-IR and Raman microspectroscopy to examine the molecular structure of mouse oocytes, revealing how their morphology changes as they mature from germinal vesicle (GV) to metaphase II (MII) stages.
- The study found that immature GV oocytes have a small lipid deposit, while mature MII oocytes possess much larger lipid deposits, each with distinct inner and outer lipid environments.
- Analyzing data from multiple trials with principal component analysis (PCA), the researchers identified specific spectral changes in the CH stretching region, suggesting a method for assessing oocyte maturation and lipid distribution at the single-cell level.