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Publications by authors named "Alica Brettschneider"

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Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidaemia and early atherogenesis.
Carmen Hannemann Johannes H Schecker Alica Brettschneider Jana Grune Nicole Rösener

Cardiovasc Res

January 2022

Aims: Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall and anti-inflammatory treatment strategies are currently pursued to lower cardiovascular disease burden. Modulation of recently discovered inactive rhomboid protein 2 (iRhom2) attenuates shedding of tumour necrosis factor-alpha (TNF-α) selectively from immune cells. The present study aims at investigating the impact of iRhom2 deficiency on the development of atherosclerosis.

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Synopsis of recent research by authors named "Alica Brettschneider"

  • - Alica Brettschneider's research focuses on the role of inactive rhomboid protein 2 (iRhom2) in the context of atherosclerosis and hyperlipidemia, aiming to explore its potential as a therapeutic target in cardiovascular diseases.
  • - The findings from Brettschneider's study indicate that deficiency of iRhom2 significantly reduces diet-induced hyperlipidemia and early atherogenesis, suggesting a protective role against the progression of atherosclerosis.
  • - The research emphasizes the importance of targeting the shedding of tumor necrosis factor-alpha (TNF-α) from immune cells, which could lead to innovative anti-inflammatory strategies for treating cardiovascular diseases.

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