Oral and gut microbial profiling in periodontitis and Parkinson's disease.

Objectives: We tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome.

Method: Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded.

Parkinson's disease alters the composition of subgingival microbiome.

Aim: The current study aimed to test the hypothesis that Parkinson's disease exacerbates periodontitis by altering its microbiome.

Materials And Methods: Clinical periodontal parameters were recorded. Subgingival samples from healthy controls, periodontitis patients (PD), and Parkinson's patients with periodontitis (PA+PD) were analyzed using the checkerboard DNA-DNA hybridization technique for targeting 40 bacterial species typically associated with periodontal disease and health.

Parkinson's disease is positively associated with periodontal inflammation.

Background: Parkinson's disease (PA) affects 1% of the global population above 60 years. PA pathogenesis involves severe neuroinflammation that impacts systemic and local inflammatory changes. We tested the hypothesis that PA is associated with periodontal tissue inflammation promoting a greater systemic inflammatory burden.

The therapeutic effect of deep brain stimulation on olfactory functions and clinical scores in Parkinson's disease.

Deep brain stimulation (DBS) is still a highly effective treatment option that significantly improves motor function in advanced PD. Moreover, previous findings have shown that Olfactory dysfunction (OD) has been found in a majority of patients with Parkinson's Disease (PD). Despite this, the effect of DBS on the olfactory function is not fully understood.

A standardisable model of focal cerebral ischaemia innormotensive rats.

In this study various techniques with different periods of ischaemia have been used in order to describe a standardisable and reproducible model of reversible focal cerebral ischaemia in normotensive rats. Cerebral blood flow to the left hemisphere of the rats was temporarily interrupted by middle cerebral artery occlusion only in four rats of each group, by simultaneous middle cerebral artery and ipsilateral common carotid artery occlusion in six rats of each group, and by middle cerebral artery and bilateral common carotid artery occlusion in six rats of each group. Within each group temporary ischaemia lasted for 1, 2 or 3 h and animals survived for 24 h following reperfusion.