In vitro evaluation of effects of sustained anti-TNF release from MPEG-PCL-MPEG and PCL microspheres on human rheumatoid arthritis synoviocytes.

Anti-tumor necrosis factor α (TNFα) drugs such as etanercept (ETN) have been mostly used in systemic treatment of rheumatoid arthritis. To eliminate the side effects in long-term treatments and to achieve a local sustained anti-inflammatory effect, a controlled drug delivery system is needed for anti-TNFα drugs. This study aims to develop novel injectable microcarriers of ETN that can provide long-term controlled release of this protein drug upon intra-articular application.

Characteristics and release profiles of MPEG-PCL-MPEG microspheres containing immunoglobulin G.

Polyester-polyether type block copolymers have attracted attention in the area of drug delivery systems with their capability in providing a broad range of amphiphilic characteristics. The aim of the present work was to prepare and characterize immunoglobulin G (IgG) loaded methoxy poly(ethylene glycol)-poly(ɛ-caprolactone)-methoxy poly(ethylene glycol) (MPEG-PCL-MPEG) microspheres as potential carrier for therapeutic monoclonal antibodies used in clinics. MPEG-PCL-MPEG triblock copolymer was synthesized by ring-opening polymerization of ɛ-caprolactone initiated by MPEG and then characterized.

In vitro comparison of autoclave polymerization on the transverse strength of denture base resins.

The aim of this study was to determine the effect of autoclave polymerization on the transverse strength of denture base polymers. To this end, 30 rectangular test specimens were fabricated of two heat-polymerized denture base polymers. The test groups were: (I) control, i.

Structure-property relation of a soft liner material used in denture applications.

With a view to understanding the structure-property relation of a silicone-based soft lining denture material after polymerization, its chemical composition and viscoelastic properties were investigated. Chemical compositions of the cured and uncured polymers of a commercial silicone permanent soft liner were determined by infrared spectroscopic analysis, nuclear magnetic resonance (NMR), and X-ray photoelectron spectroscopy. Dynamic mechanical analysis (DMA) method was used to investigate the viscoelastic behavior of the cured polymer of liner.

Dynamic mechanical analysis of provisional resin materials reinforced by metal oxides.

In this study, several provisional resin materials were investigated by dynamic mechanical analysis (DMA). The materials were autopolymerized PMMA and PEMA, light cured PMMA. Autopolymerized PMMA has the highest T(g) (131 degrees C) compared to that of the autopolymerized PEMA (102 degrees C) and light cured PMMA (120 degrees C).