Publications by authors named "Ali Tureyen"
Cisplatin (CIS) is a chemotherapeutic agent frequently used in cancer treatment. However, depending on the dosage and duration of use, CIS can lead to hepatotoxicity and nephrotoxicity. Iristectorin A (IRIS), a natural flavonoid, has been found to exhibit antioxidant and protective effects.
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- The study looked at how magnolin (MAG) protects rats from damage caused by a drug called cyclophosphamide (CP).
- When rats were given CP, it hurt their organs and increased harmful substances in their bodies.
- Treatment with MAG helped improve these problems by reducing stress and inflammation in their bodies.
The most prominent adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (DF) are hepato-renal damage. Natural antioxidants can be preferred as an alternative and/or combination to improve this damage. This present study was conducted to evaluate the protective effect of Tubuloside A (TA) against diclofenac (DF)-induced hepato-renal damage.
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- 2,4-Dichlorophenoxyacetic acid (2,4-D) and arsenic both pose significant biological toxicity, but their combined effects and mechanisms in co-exposure are not fully understood.
- A study involving four-week-old female rats showed that co-exposure to both substances for 28 days led to increased biochemical indicators of liver and kidney damage, altered hormonal levels, and evidence of oxidative stress, including lipid peroxidation and decreased antioxidant enzymes.
- Additionally, significant DNA damage and increased apoptotic and inflammatory markers were observed in co-exposed groups, along with more severe tissue damage compared to exposure to each substance individually.
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- This study aimed to understand the long-term gastrointestinal effects and gut-brain interaction disorders in patients hospitalized for COVID-19 compared to those without the infection.
- The analysis included data from 883 patients, revealing that gastrointestinal symptoms were more prevalent in COVID-19 patients during hospitalization, but by the 12-month follow-up, controls reported higher rates of constipation and hard stools.
- Additionally, COVID-19 patients showed a significantly higher prevalence of irritable bowel syndrome (IBS) compared to controls, with certain factors like allergies and medication usage being associated with IBS diagnosis.
Clarifying the interactions between substances as a result of exposure to multiple xenobiotics and determining the impacts on health are important from the toxicological point of view. Therefore, the aim of the study was to investigate the synergistic toxic effects of ethanol and 2,4-dichlorophenoxyacetic acid (2,4-D) in male albino rats. A total number of 28 Wistar male rats were divided into 4 groups (7/each), and 2,4-D (5 mg/kg) and ethanol (3 g/kg) were administered orally to rats for 60 days, either alone or in combination.
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- A study examined the prevalence of gastrointestinal (GI) symptoms in hospitalized COVID-19 patients compared to non-COVID patients, confirming that GI symptoms are more common in those with COVID-19 (59.7% vs. 43.2%).
- The study involved 2036 patients and used a specific questionnaire to assess GI symptoms at hospital admission and after one month.
- Key findings include a reduction in GI symptoms over time in COVID-19 patients, but persistent nausea was associated with factors like female sex, high body mass index, dyspnea, and elevated C-reactive protein levels.
Background/aims: The aim of this study was to investigate the frequency of sacroileitis and ankylosing spondylitis in inflammatory bowel disease and the relationship between disease activity, joint symptoms and HLA-B27 antigen positivity.
Methods: Sacroiliac joint radiography and three phase bone scanning of 33 ulcerative colitis patients (17 active and 16 in remission) and 29 Crohn's disease patients (15 active and 14 in remission) was performed. HLA-B27 was determined in all patients and 60 control subjects.