Publications by authors named "Ali Tugrul Akİn"
Effect of vitamin B12 on methotrexate-induced cardiotoxicity in rats.
Iran J Basic Med Sci
January 2024
Article Synopsis
- - This study investigates the cardiotoxic effects of methotrexate (MTX), a chemotherapy drug, and the potential protective role of vitamin B12 in mitigating this toxicity in rats.
- - Rats were divided into four groups: a control group, a vitamin B12 group, an MTX group, and a combined MTX and vitamin B12 group, with various biomarkers and tissue expressions evaluated to assess heart health.
- - The results showed MTX caused significant negative changes in heart-related factors and that vitamin B12 effectively normalized these changes, emphasizing the importance of vitamin B12 supplementation during MTX treatment.
Effects of adriamycin on cell differentiation and proliferation in rat testis.
Biotech Histochem
November 2023
Article Synopsis
- Adriamycin (ADR), a cancer treatment, harms healthy organs like the testis, prompting a study on its effects on pluripotency in rat testis.
- Rats were split into three groups: untreated control, cumulative dose ADR, and single dose ADR, with various evaluations conducted for testicular damage and spermatogenic cell marker expressions.
- Results showed decreased seminiferous tubule diameters, lower expression of key pluripotency markers, and reduced testosterone levels in both ADR-treated groups, indicating ADR's detrimental impact on testicular function and maintenance of pluripotency.
Article Synopsis
- * The study involved administering NP and TQ to different rat groups to evaluate the effects on brain health and behavior, using various tests and tissue evaluations.
- * Results indicated that NP caused significant brain damage and behavioral issues, but TQ treatment improved these conditions by reducing neuron degeneration and oxidative stress markers.
Aims: Demyelination affects the propogation of neuronal action potential by slowing down the progression. This process results in a neuro-impairment like Multiple Sclerosis (MS). Evidence show that MS also contributes to involvement of the autonomic system.
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- Doxorubicin (DOX) is an effective cancer drug but causes kidney damage as a side effect, prompting research on protective agents.
- Thymoquinone (THQ), a natural compound with antioxidant and anti-inflammatory properties, was tested on rats to see if it could mitigate DOX-induced kidney toxicity.
- Results showed that THQ significantly reduced kidney damage and improved kidney function by lowering markers of inflammation and apoptosis compared to the DOX-only group.
Article Synopsis
- Chronic hypoxia harms male fertility by causing changes in the reproductive system, but the mechanisms behind this damage remain unclear.
- This study explored the use of chloroquine (CLQ), an anti-inflammatory drug, to treat testicular damage caused by hypoxia in Wistar albino rats, assessing various biological markers and responses.
- Results indicated that hypoxia led to increased histopathological changes and decreased testosterone levels, while CLQ treatment significantly improved these negative effects, suggesting its potential as a protective agent for male fertility.
Background And Purpose: Research on the relationship between the gut microbiome and epilepsy is accumulating. The present study was conducted to evaluate the effect of probiotic supplementation on pentylenetetrazole (PTZ)-induced seizures in rats.
Methods: Twenty-one adult male Wistar albino rats were included.
Aim: Epilepsy is one of the most common chronic brain disorders that affect millions of people worldwide. In the present study, we investigated the effects of probiotic supplementation on absence epilepsy and anxiety-and depression-like behavior in WAG/Rij rats.
Material And Method: Fourteen male WAG/Rij rats (absence-epileptic) and seven male Wistar rats (nonepileptic) were used.
Article Synopsis
- Cancer leads to uncontrolled cell growth and can cause death, and while doxorubicin (DOX) is often used to treat various cancers, it can cause severe liver damage.
- This study investigated the protective effects of thymoquinone (THQ) against DOX-induced liver toxicity in rats, using different treatment groups to assess changes in liver health.
- Results showed that THQ improved liver conditions by reducing apoptosis and inflammatory markers in the presence of DOX, suggesting it could potentially mitigate the liver damage associated with DOX treatment.
Article Synopsis
- Doxorubicin (DOX), a common cancer treatment, can lead to neurotoxicity, prompting researchers to explore thymoquinone (THQ), a strong antioxidant, for its protective effects.
- The study involved 40 rats divided into five groups to assess various treatments, including THQ alone, DOX alone, and a combination of both.
- Results showed that THQ significantly reduced harmful proteins associated with neurotoxicity and improved antioxidant levels in the brain, suggesting it may have protective benefits against DOX-induced damage.
Article Synopsis
- Methotrexate (MTX) is an anti-cancer drug that can harm the testes, while Vitamin B12 (Vit B12) is essential for normal metabolism.
- The study tested whether Vit B12 could protect against testicular damage from MTX by organizing four groups of rats with different treatments over 15 days.
- Results showed that the MTX group had significant testicular degeneration and hormonal changes, but these negative effects were largely reversed in the group treated with both MTX and Vit B12, suggesting that Vit B12 may help protect against MTX-induced damage.
Article Synopsis
- The study investigates the toxic effects of carbon tetrachloride (CCL) on liver tissue and the potential protective benefits of L-carnitine.
- Forty rats were divided into five groups to analyze the different impacts of CCL and L-carnitine administration, focusing on biochemical markers and histological changes.
- Results showed that while CCL exposure led to increased protein expression linked to liver damage, L-carnitine administration before or after CCL treatment improved tissue condition and reduced detrimental protein levels.
Effects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinase.
Naunyn Schmiedebergs Arch Pharmacol
December 2020
In the study, we aimed to show the effects of vitamin B12 on the necrosis caused by methotrexate (MTX), a folic acid antagonist. Thirty-two rats were randomly assigned to four groups of eight rats per group. Control (n = 8), Vit B12 (n = 8) 3 μg/kg/ip B12 (15 days) per day throughout the experiment, MTX (n = 8) injected with a single dose of 20 mg/kg/ip MTX on 8th day of experiment, MTX + Vit B12 (n = 8) injected with a single dose of 20 mg/kg ip methotrexate on 8th day of experiment + 3 μg/kg/ip Vit B12 (15 days) per day throughout the experiment.
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- Pulmonary arterial hypertension (PAH) is a serious condition with high blood pressure in the lungs and changes in blood vessel structure; this study looks at the effects of chloroquine (CLQ) on certain receptor proteins involved in calcium signaling in a model of PAH.
- The research used male Wistar albino rats divided into four groups to compare the effects of hypoxia and treatment with chloroquine, measuring changes in blood vessel structure and protein expression related to calcium receptors.
- Results showed that while hypoxia increased the thickness of blood vessel walls and levels of calcium receptors, chloroquine treatment significantly reduced these changes, suggesting CLQ's potential to inhibit calcium influx in PAH.
Article Synopsis
- Doxorubicin is an effective chemotherapy drug but has significant cardiotoxic side effects that need addressing.
- The study investigates thymoquinone, a compound known for its ability to scavenge free radicals, as a potential protective agent against the heart damage caused by doxorubicin.
- Forty rats were used in the experiment, divided into five groups, with results indicating that thymoquinone significantly reduced the harmful effects of doxorubicin on heart tissue and overall cardiac health.