Publications by authors named "Ali Tfaily"
To optimize the clinical approach to non-convulsive status epilepticus (NCSE), it is essential to gain insight into its long-term effects on cognition and behaviors. Here, we investigated limbic NCSE-induced hippocampal injury and behavioral deficits in peri-adolescent rats. NCSE was induced in P43 Sprague Dawleyrats with intrahippocampal subconvulsive doses of kainic acid (NCSE group, n = 14) under continuous epidural cortical electroencephalography (EEG).
View Article and Find Full Text PDFSpinal cord injury remains a major cause of disability in young adults, and beyond acute decompression and rehabilitation, there are no pharmacological treatments to limit the progression of injury and optimize recovery in this population. Following the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation, a similar role for complement in spinal neuroinflammation is a focus of ongoing research. In this work, we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins, triggers of complement activation, and role of effector functions in the pathology.
View Article and Find Full Text PDFDysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer's Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally-relevant insights. We used cell-type-specific in-vivo biotinylation of proteins (CIBOP) coupled with mass spectrometry to obtain native-state PV-IN proteomes.
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- Awake surgery using spinal anesthesia (SA) has been found to have benefits over general anesthesia (GA) in terms of shorter hospital stays and surgical times in spine surgeries.
- A systematic review analyzed 38 studies involving 7,820 patients and revealed that patients under SA experienced fewer complications, including lower rates of postoperative nausea and urinary retention compared to those under GA.
- The findings suggest that awake spine surgery could be a preferable option, offering both reduced surgical duration and fewer negative postoperative outcomes.
One of the earliest pathophysiological perturbations in Alzheimer's Disease (AD) may arise from dysfunction of fast-spiking parvalbumin (PV) interneurons (PV-INs). Defining early protein-level (proteomic) alterations in PV-INs can provide key biological and translationally relevant insights. Here, we use cell-type-specific in vivo biotinylation of proteins (CIBOP) coupled with mass spectrometry to obtain native-state proteomes of PV interneurons.
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- * This diet is linked to the metabolic syndrome and lower cognitive performance, while the ketogenic diet, which is high in fat and low in carbohydrates, has shown potential benefits for brain health and has been used to treat seizures since the 1920s.
- * The article emphasizes the impact of different diets on brain metabolism and neurological diseases, urging more research into the ketogenic diet's therapeutic effects and the need for standardized dietary formulations in clinical trials.