Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space.

Electrical stimulation (ES) through biomaterials and devices has been implicated in activating diverse cell behaviors while facilitating tissue healing process. Despite its significance in modulating biological events, the mechanisms governing ES-activated cellular phenomena remain largely elusive. Here, we demonstrated that millisecond-pulsed temporal ES profoundly impacted a spectrum of cellular events across the membrane-cytosol-nuclear space.

Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial-Stromal Interplay in Cancer Development.

Epithelial-stromal interplay through chemomechanical cues from cells and matrix propels cancer progression. Elevated tissue stiffness in potentially malignant tissues suggests a link between matrix stiffness and enhanced tumor growth. In this study, employing chronic oral/esophageal injury and cancer models, it is demonstrated that epithelial-stromal interplay through matrix stiffness and Hedgehog (Hh) signaling is key in compounding cancer development.

Targeting Nuclear Mechanics Mitigates the Fibroblast Invasiveness in Pathological Dermal Scars Induced by Matrix Stiffening.

Pathological dermal scars such as keloids present significant clinical challenges lacking effective treatment options. Given the distinctive feature of highly stiffened scar tissues, deciphering how matrix mechanics regulate pathological progression can inform new therapeutic strategies. Here, it is shown that pathological dermal scar keloid fibroblasts display unique metamorphoses to stiffened matrix.

Advanced materials technologies to unravel mechanobiological phenomena.

Advancements in materials-driven mechanobiology have yielded significant progress. Mechanobiology explores how cellular and tissue mechanics impact development, physiology, and disease, where extracellular matrix (ECM) dynamically interacts with cells. Biomaterial-based platforms emulate synthetic ECMs, offering precise control over cellular behaviors by adjusting mechanical properties.

Mussel-inspired biomaterials: From chemistry to clinic.

After several billions of years, nature still makes decisions on its own to identify, develop, and direct the most effective material for phenomena/challenges faced. Likewise, and inspired by the nature, we learned how to take steps in developing new technologies and materials innovations. Wet and strong adhesion by mussels (among which -blue mussel and -California mussel are the most well-known species) has been an inspiration in developing advanced adhesives for the moist condition.

Cell Membrane-Cloaked Nanotherapeutics for Targeted Drug Delivery.

Cell membrane cloaking technique is bioinspired nanotechnology that takes advantage of naturally derived design cues for surface modification of nanoparticles. Unlike modification with synthetic materials, cell membranes can replicate complex physicochemical properties and biomimetic functions of the parent cell source. This technique indeed has the potential to greatly augment existing nanotherapeutic platforms.

Hydrogel membranes: A review.

Hydrogel membranes (HMs) are defined and applied as hydrated porous media constructed of hydrophilic polymers for a broad range of applications. Fascinating physiochemical properties, unique porous architecture, water-swollen features, biocompatibility, and special water content dependent transport phenomena in semi-permeable HMs make them appealing constructs for various applications from wastewater treatment to biomedical fields. Water absorption, mechanical properties, and viscoelastic features of three-dimensional (3D) HM networks evoke the extracellular matrix (ECM).

Metal-Organic Framework (MOF)/Epoxy Coatings: A Review.

Epoxy coatings are developing fast in order to meet the requirements of advanced materials and systems. Progress in nanomaterial science and technology has opened a new era of engineering for tailoring the bulk and surface properties of organic coatings, e.g.

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering.

The lack of adequate blood/lymphatic vessels as well as low-potential articular cartilage regeneration underlines the necessity to search for alternative biomaterials. Owing to their unique features, such as reversible thermogelling behavior and tissue-like mechanical behavior, agarose-based biomaterials have played a key role in cartilage tissue repair. Accordingly, the need for fabricating novel highly efficient injectable agarose-based biomaterials as hydrogels for restoration of injured cartilage tissue has been recognized.

From microporous to mesoporous mineral frameworks: An alliance between zeolite and chitosan.

Microporous and mesoporous minerals are key elements of advanced technological cycles nowadays. Nature-driven microporous materials are known for biocompatibility and renewability. Zeolite is known as an eminent microporous hydrated aluminosilicate mineral containing alkali metals.

Synthesis of pearl necklace-like ZIF-8@chitosan/PVA nanofiber with synergistic effect for recycling aqueous dye removal.

Recently, fabrication of MOF-based bionanocomposites for wastewater treatment applications is enjoying wide currency. Herein, zeolitic imidazolate framework-8 (ZIF-8) crystal was coated on chitosan/polyvinyl alcohol electrospun nanofiber (CS/PVA-ENF) to synthesize ZIF-8@CS/PVA-ENF. They were characterized, and their dye adsorption performances were studied in detail.

In situ deposition of Ag/AgCl on the surface of magnetic metal-organic framework nanocomposite and its application for the visible-light photocatalytic degradation of Rhodamine dye.

Herein, NH-MIL-125(Ti) (NMT) as one of the known stable metal-organic frameworks (MOFs) in aqueous solution was successfully magnetized with CoFeO nanoparticles through the hydrothermal method. The Ag/AgCl as a plasmonic photocatalyst was assembled on the CoFeO/NMT (CFNMT) at room temperature by in situ deposition, and photo-reduction methods to improve the photocatalytic activity of CFNMT under LED visible light. The prepared materials were fully characterized by SEM/EDX, TEM, FTIR, XRD, UV-DRS, and VSM analysis.

The Incidence of Deep Vein Thrombosis in Breast Cancer Patients Receiving Outpatient Cancer Therapy in Iran.

Background: Venous thromboembolism (VTE) is one of the main causes of mortality in patients with cancer. This study was conducted to assess the incidence of deep vein thrombosis (DVT) in breast cancer patients receiving outpatient cancer therapy.

Materials And Methods: This multi-center prospective cohort study was conducted on patients with breast cancer, initiating an outpatient chemotherapy regimen in five medical centers in Iran.

Novel magnetic amine functionalized carbon nanotube/metal-organic framework nanocomposites: From green ultrasound-assisted synthesis to detailed selective pollutant removal modelling from binary systems.

Herein, magnetic amine functionalized carbon nanotube (NH-CNT/FeO)-zeolitic imidazolate framework-8 (ZIF-8) nanocomposites (NH-CNT/FeO/ZIF-8: NCFZ) with different amounts of NH-CNT/FeO (5, 10, and 15 wt% denoted as NCFZ-5, NCFZ-10, and NCFZ-15) were synthesized. The synthesized nanomaterials including ZIF-8, FeO, CNT/FeO, NH-CNT/FeO, CNT/FeO/ZIF-8, NCFZ-5, NCFZ-10, and NCFZ-15 were characterized using BET, TEM, XRD, SEM, FTIR, VSM and zeta potential. The synthesized nanomaterials were applied for selective removing cationic dyes (MG: Malachite Green and RhB: Rhodamine B) from a binary system.

Activated carbon/metal-organic framework nanocomposite: Preparation and photocatalytic dye degradation mathematical modeling from wastewater by least squares support vector machine.

Herein, Kiwi peel activated carbon (AC), Materials Institute Lavoisier (MIL-88B (Fe), and AC/MIL-88B (Fe) composite were synthesized and used as catalysts to degrade Reactive Red 198. The material properties were analyzed by the FTIR, BET-BJH, XRD, FESEM, EDX, TGA, and UV-Vis/DRS. The BET surface area of AC, MIL-88B (Fe) and AC/MIL-88B (Fe) was 1113.

Effect of Persian Medicine Remedy on Chemotherapy Induced Nausea and Vomiting in Breast Cancer: A Double Blind, Randomized, Crossover Clinical Trial.

Background: Chemotherapy induced nausea and vomiting (CINV) is a side effect, and has negative effect on quality of life and continuation of chemotherapy. Despite new regimen and drugs, the problems still remain and standard guidelines, effective treatment and supportive care for refractory CINV are still not yet established. Persian medicine, the old Iranian medical school, offer Persumac (prepared from Rhus Coriaria and Bunium Persicum Boiss).

Nausea and vomiting in Iranian Traditional Medicine based on Avicenna's viewpoint.

Background: Nausea and vomiting decrease one's quality of life significantly, and, despite various treatments, they are still uncontrollable, especially in acute illness. Perhaps it would be useful to search for new concepts and therapies for dealing with these issues at other medical schools. The aim of this research was to elucidate the causes of nausea and vomiting in Iranian Traditional Medicine (ITM) based on Avicenna's viewpoint in The Book of "Canon of medicine".

Multicentric myxoid liposarcoma; a case report and literature review.

Liposarcoma is a common malignant soft tissue tumor, accounting for 10% to 16% of all sarcomas. Multicentric myxoid liposarcoma is an uncommon condition. Differentiation between several primary tumors and metastasis of a single liposarcoma represents the main difficulty in diagnosis.

Attitude of cancer patients toward diagnosis disclosure and their preference for clinical decision-making: a national survey.

Objectives: There is still contradictory evidence on disclosure preferences regarding cancer diagnosis. The aim of this study was to evaluate the preference of cancer patients for knowing the truth about their disease, as well as the factors that might have an impact on these preferences.

Method: This study was conducted in 11 cancer centers in Iran.

Prevalence of occult metastases in axillary sentinel lymph nodes of breast carcinoma.

Recently, sentinel lymph node biopsy (SLNB) has been accepted as a standard method of assessment of axillary lymph nodes in breast cancer patients with no clinical lymphadenopathy. There is no standard pathologic method to evaluate sentinel lymph nodes. The purpose of this study is to evaluate the frequency of occult lymph node metastasis in sentinel lymph nodes via serial sectioning and immunohistochemical study with cytokeratin and its relationship with other clinicopathologic factors.

Comparison of hormone receptor status in primary and recurrent breast cancer.

Background: Systematic treatments such as hormone and chemotherapy are selected according to tumor characteristic after major therapeutic approaches such as surgery. This study attempted to analyze and compare the status of Estrogen Receptor (ER) and Progesterone Receptor (PR) in primary and recurrent sites of breast cancer in patients.

Methods: We reviewed all medical records of breast cancer women who were treated between January 1995 and December 2008.