Publications by authors named "Ali Serdar Oguzoglu"
Article Synopsis
- - The study investigates how subarachnoid hemorrhage (SAH) affects oxidative stress and inflammation in the brain and heart by using Wistar Albino rats, comparing a sham group with one that experienced SAH.
- - After 7 days, results showed increased levels of oxidative stress indicators (TOS, OSI) and inflammation markers (GFAP, NFkβ, IL-6, Cox-1) in the tissues, while antioxidant mechanisms (TAS, AKT, SIRT-1, NRF2, HO-1) were found to be reduced.
- - The findings suggest that SAH leads to a suppression of antioxidant pathways and an enhancement of inflammatory responses, indicating a need for targeted treatments that
Transoral penetrating foreign body injury of the neck involving the cervical spine is a rare condition. We present an injury caused by transoral penetration of a broken piece of a wooden plank into the neck with injury to the upper cervical spine in a 31-year-old male patient. The foreign body was removed transorally with the patient making a full recovery under close observation and was discharged and followed up with no complications.
View Article and Find Full Text PDFObjective: To evaluate functional outcome after combined radiofrequency ablation and vertebral augmentation in patients with metastatic spinal tumors using visual analog scale and Oswestry Disability Index scores.
Methods: This retrospective study included 41 patients with metastatic spinal tumors. There were 19 women and 22 men with a mean age of 67 years (range, 45-87 years).
Objectives: Intradiscal ozone treatment is a minimally-invasive method that can be applied to patients who have low back pain and do not respond to conservative treatment. This retrospectively designed study aimed to evaluate its clinical efficacy, adverse effects, or complication rates.
Methods: Patients with lumbar degenerative disc disease (LDDD) who underwent intradiscal O-O treatment between January 2016 and April 2018 were included in the study.
Objectives: To evaluate the effect of vertebroplasty (VP) alone or combined therapy of radiofrequency ablation (RFA) with vertebroplasty on pain relief with visual analog scale (VAS) and Oswestry Disability Index (ODI) scores in vertebral hemangiomas.
Methods: Forty-six patients with hemangiomas were evaluated retrospectively: 20 males and 26 females were included. In group 1 ( = 25) only VP was performed, while RFA+VP were performed in the same treatment session in group 2 ( = 21).
Background: Perfusion abnormalities due to vasospasm remain a major cause of morbidity and mortality in subarachnoid hemorrhage (SAH). Despite a large number of clinical trials, therapeutic options with strong evidence for prevention and treatment of cerebral vasospasm are rare. In this study, we aimed to evaluate the neuroprotective effect of salubrinal (SLB) in endoplasmic reticulum stress-induced apoptosis, a catastrophic consequence of vasospasm.
View Article and Find Full Text PDFObjective: We investigated the effects of different doses of pregabalin on the pathophysiologic changes in early brain injury after subarachnoid hemorrhage (SAH) in rats.
Methods: Thirty-eight Wistar albino rats were divided into 4 groups: control (n = 8), SAH (n = 10), SAH plus 30 mg/kg/day of pregabalin (n = 10), and SAH plus 60 mg/kg/day of pregabalin (n = 10). SAH was induced with 0.