Publications by authors named "Ali Sadeghian Shahi"
Article Synopsis
- Doctors are studying a treatment called dual antiplatelet therapy (DAPT) for patients who have brain aneurysms that have burst.
- They looked at two groups of patients: one that received DAPT and another that did not, to see how safe it was after surgery.
- The results showed that while there were some issues for the DAPT group, like bleeding, it may help reduce other problems, like lack of blood flow to the brain.
Potential anti-inflammatory effect of anti-HMGB1 in animal models of ICH by downregulating the TLR4 signaling pathway and regulating the inflammatory cytokines along with increasing HO1 and NRF2.
Ji Xu Sahar Mashayekhi Firouz Mina Farrokhian Shadi Ghoreishizadeh Talar Ahmad Merza Mohamad Ali Sadeghian Shahi
Eur J Pharmacol
January 2022
Intracerebral hemorrhage (ICH) is a severe clinical problem without effective treatment; the leading cause is neuroinflammation. High-mobility group box one protein (HMGB1) is an abundant protein in the cell nucleus of most mammalian cells, which exerts its function by binding to chromatin. The present study focused on the therapeutic effect of anti-HMGB1 on ICH via the downregulation of inflammatory pathways.
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