Chlorpromazine versus clotiapine for schizophrenia.

Background: Schizophrenia is a chronic, disabling and severe mental disorder, characterised by disturbance in perception, thought, language, affect and motor behaviour. Chlorpromazine and clotiapine are among antipsychotic drugs used for the treatment of people with schizophrenia.

Objectives: To determine the clinical effects, safety and cost-effectiveness of chlorpromazine compared with clotiapine for adults with schizophrenia.

Associations between components of metabolic syndrome and cognition in patients with schizophrenia.

The metabolic syndrome and cognitive dysfunctions are common in patients with schizophrenia, yet there is no general consensus concerning the effects of the components of the metabolic syndrome on various cognitive domains. The goal of this study was to investigate the relationship between components of the metabolic syndrome and cognition in patients with schizophrenia. Components of the metabolic syndrome and neurocognitive functioning were assessed in 68 patients with schizophrenia.