Publications by authors named "Ali Razei"
Article Synopsis
- Sulfur mustard (SM) is a harmful chemical that causes serious eye damage, and the study focuses on comparing the anti-inflammatory effects of curcumin and doxycycline in treating corneal injuries induced by a similar agent, CEES.
- The research utilized the HCE-2 cell line to assess effective concentrations and measure changes in gene expression and activity of MMP-2 and MMP-9 enzymes after treatment.
- Results showed that both curcumin and doxycycline reduced MMP expression and activity, with curcumin demonstrating a stronger effect on MMP-9 compared to doxycycline, suggesting potential use as anti-inflammatory treatments for chemical eye injuries.
Nano and microparticle drug delivery systems for the treatment of Brucella infections.
Biomed Pharmacother
December 2023
Nano-based drug delivery systems are increasingly used for diagnosis, prevention and treatment of several diseases, thanks to several beneficial properties, including the ability to target specific cells or organs, allowing to reduce treatment costs and side effects frequently associated with chemotherapeutic medications, thereby improving treatment compliance of patients. In the field of communicable diseases, especially those caused by intracellular bacteria, the delivery of antibiotics targeting specific cells is of critical importance to maximize their treatment efficacy. Brucella melitensis, an intracellular obligate bacterium surviving and replicating inside macrophages is hard to be eradicated, mainly because of the low ability of antibiotics to enter these phagocityc cells .
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- The study investigates the healing effects of hyaluronic acid from human umbilical cords and exosomes from fibroblast cells on burn wounds in rats, comparing them with phenytoin and a control group receiving no treatment.
- Results showed that both hyaluronic acid and exosome treatments significantly improved parameters of wound healing, particularly in re-epithelialization and eschar formation.
- The findings suggest that while hyaluronic acid is better for promoting re-epithelialization, exosomes are more effective in reducing eschar formation, indicating their potential as alternatives to traditional wound treatments.
The newly emerged coronavirus (SARS-CoV-2) continues to infect humans, and no effective treatment has yet been found. Antibody therapy is one way to control infection caused by COVID-19. However, the use of classical antibodies raises complex issues.
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- The study focused on using chitosan nanoparticles to enhance the delivery of gentamicin to treat intracellular bacterial infections, like those caused by Brucella, which are hard to eliminate due to their survival within immune cells.
- Chitosan nanoparticles were created with a size of about 100 nm and showed a 22% drug loading capacity, releasing around 70% of gentamicin within the first 8 hours during testing.
- The results indicated that gentamicin-loaded chitosan nanoparticles were more effective against the bacteria in infected murine cells compared to free gentamicin, suggesting their potential for treating intracellular bacterial infections.
Presenting a rapid method for detection of , and in food samples.
Iran J Basic Med Sci
September 2017
Objectives: and are three toxin producing bacteria over the world, especially in Iran, and it is essential to find a certain, rapid procedure to identify these microorganisms. In this research, these bacteria were simultaneously detected by multiplex PCR technique in foods.
Materials And Methods: The primary approval of bacterial strains was performed by biochemical tests.