Publications by authors named "Ali Osouli"
Article Synopsis
- Autosomal dominant polycystic kidney disease (ADPKD) leads to kidney damage due to uncontrolled cyst growth and may require a combination of therapies targeting multiple signaling pathways for better treatment outcomes.
- Researchers developed peptide amphiphile micelles containing specific drug combinations (bardoxolone methyl, octreotide, salsalate, pravastatin) to enhance targeted delivery to affected kidney cells.
- Results showed that these RGD micelles significantly improved drug accumulation in the kidneys and increased therapeutic efficacy in ADPKD mouse models compared to free drugs, indicating potential for better treatment strategies.
Microtubule affinity-regulating kinase 4 (MARK4) is a Ser/Thr protein kinase, best known for its role in phosphorylating microtubule associated proteins, causing their detachment from microtubules. In the current study, the non-phosphorylated conformation of the activation loop was modeled in a structure representing the enzymatically inactive form of this protein, and its dynamics were evaluated through a 100 ns initial all-atom simulation, which was prolonged by another 2 μs. Although the activation loop was folding on itself and was leaning toward ATP site in the initial modeled structure, soon after the initiating the simulation, this loop stretched away from the ATP binding site and stably settled in its new position for the rest of simulation time.
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