Publications by authors named "Ali Nabbouh"

Background: Dental infections, which are the main cause of tooth loss, are known to be caused by bacteria. However, recent research suggests that other organisms, such as viruses, may also play a role. In this study, we aim to detect the presence of human papillomavirus (HPV)-16 and assess its prevalence in tissues infected with various dental infections, including aggressive and chronic periodontitis, pericoronitis, and periapical infection, as well as healthy gingival tissues, saliva, and gingival crevicular fluid, for comparison.

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Clinical studies showed that dextran sulfate sodium (DSS) alleviates stroke, diabetic retinopathy and hypercholesterolemia, yet its mechanism of action was unrevealed. This study show that DSS reduces hyperglycemia, plasma insulin and enhances glucose utilization by attenuating ROS production, suggesting a novel therapeutic use of DSS in diabetes and its complication.

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Traumatic brain injury (TBI) has been recognized as one of the major public health issues that leads to devastating neurological disability. As a consequence of primary and secondary injury phases, neuronal loss following brain trauma leads to pathophysiological alterations on the molecular and cellular levels that severely impact the neuropsycho-behavioral and motor outcomes. Thus, to mitigate the neuropathological sequelae post-TBI such as cerebral edema, inflammation and neural degeneration, several neurotherapeutic options have been investigated including drug intervention, stem cell use and combinational therapies.

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Article Synopsis
  • - Nucleophosmin 1 (NPM1) mutation is common in acute myeloid leukemia (AML), leading to abnormal protein localization and contributing to cancer development; targeting the mutated form (NPM1c) shows potential for treatment.
  • - Research demonstrated that a compound called EAPB0503 selectively degrades NPM1c, restores the normal function of wild-type NPM1, and induces growth arrest and apoptosis in AML cells expressing NPM1c.
  • - The study suggests that leveraging EAPB0503 to target NPM1c could provide a new therapeutic strategy for eradicating leukemia, supporting further clinical trials.
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