Minimal Important Difference in Voice Handicap Index-10.

Importance: The minimal important difference (MID) on patient-reported outcome measures can indicate how much of a change on that scale is meaningful.

Objective: To use an anchor-based approach to estimate MID in the Voice Handicap Index-10 (VHI-10) total score.

Design, Setting, And Participants: In this cohort study, a volunteer sample of adult patients visiting the voice clinic at the University of Minnesota from April 7, 2013, through July 3, 2016, completed the VHI-10 (range, 0-40, with higher scores indicating greater voice-related handicap) at baseline and 2 weeks later in conjunction with a global rating of change.