Study of single nucleotide polymorphism (rs28368082) in SPO11 gene and its association with male infertility.

Purpose: The present study is a case-control analysis of a SNP (rs28368082) in exon 7 of the SPO11 gene and its possible association with male infertility in three provinces of Iran. We also searched for genetic differences among populations.

Methods: Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis, we genotyped 113 infertile men and 50 fertile controls.

Screening of 'Y' chromosome microdeletions in Iranian infertile males.

Background: It has been hypothesized that microdeletions of Yq may account for a significant proportion of men with infertility. Three nonoverlapping regions, referred to as "azoospermia factors" (AZFa, b, c from proximal to distal Yq) have been defined as spermatogenesis loci and deletions in these regions have been shown to be pathogenically involved in male infertility associated with azoospermia or severe oligospermia.

Aims: Evaluation the frequency of Y chromosome microdeletions in Iranian population.

ABO blood group prevalence in spontaneously repeated abortion.

The relation of ABO blood groups to disease is well established. In 1943, Levine had identified ABO incompatibility as a cause of early abortions and stillbirths. From this time onwards numerous workers produced data suggesting, mainly on the grounds of a deficiency of A children, and an excess of abortions, in the families of O women married to A men, that the A fetuses produced by such mating were especially liable to be aborted.