Dermatologic Changes in Experimental Model of Long COVID.

The coronavirus disease-19 (COVID-19) pandemic, declared in early 2020, has left an indelible mark on global health, with over 7.0 million deaths and persistent challenges. While the pharmaceutical industry raced to develop vaccines, the emergence of mutant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) strains continues to pose a significant threat.

Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis.

Pancreatitis is an inflammatory disease, which is triggered by adverse events in acinar cells of the pancreas. After the initial injury, infiltration of neutrophils in pancreas is observed. In the initial stages of pancreatitis, the inflammation is sterile.

Laccase Engineering: Redox Potential Is Not the Only Activity-Determining Feature in the Metalloproteins.

Laccase, one of the metalloproteins, belongs to the multicopper oxidase family. It oxidizes a wide range of substrates and generates water as a sole by-product. The engineering of laccase is important to broaden their industrial and environmental applications.

Enzyme engineering: Reshaping the biocatalytic functions.

Enzyme engineering is a powerful tool to fine-tune the enzymes. It is a technique by which the stability, activity, and specificity of the enzymes can be altered. The characteristic properties of an enzyme can be amended by immobilization and protein engineering.

Guar gum blended alginate/agarose hydrogel as a promising support for the entrapment of peroxidase: Stability and reusability studies for the treatment of textile effluent.

Ginger peroxidase (GP) was entrapped into the hydrogels of guar gum (GG)-alginate/agarose and these immobilized GP preparations were employed for the treatment of textile effluent. GG is a natural hydrophilic polysaccharide, the average size of which increases in its hydrated form that helps in retaining the enzyme inside the entrapping support. Therefore, the activity retention by alginate-guar gum (ANGG) and agarose-guar gum (AGG) was higher than that of alginate and agarose alone.

Immobilization of peroxidase on polypyrrole-cellulose-graphene oxide nanocomposite via non-covalent interactions for the degradation of Reactive Blue 4 dye.

In the present study novel polypyrrole-cellulose-graphene oxide nanocomposite (PCeGONC) was employed for the immobilization of ginger peroxidase (GP) via simple adsorption mechanism. Immobilization of enzyme on the obtained support resulted in enhancement of the enzyme activity. The recovery of activity was 128% of the initial activity.