Unveiling Off-Target Mutations in CRISPR Guide RNAs: Implications for Gene Region Specificity.

The revolutionary CRISPR-Cas9 technology has revolutionized genetic engineering, and it holds immense potential for therapeutic interventions. However, the presence of off-target mutations and mismatch capacity poses significant challenges to its safe and precise implementation. In this study, we explore the implications of off-target effects on critical gene regions, including exons, introns, and intergenic regions.

Psychometric evaluation of the Social Support Questionnaire for Transactions in Turkish gender-based violence sample.

Aim: This study aims to investigate the reliability and predictive validity of the Social Support Questionnaire for Transactions (SSQT) scale.

Design: A psychometric design using cross-sectional data.

Method: This cross-sectional descriptive study was conducted between February-June 2021 using snowball sampling through an online survey panel.

Evaluation of treatment responses among subgroups of breast cancer patients receiving neoadjuvant chemotherapy.

Background: Breast MRIs are helpful for determining treatment plans, responses, and prospective survival analyses. In this retrospective cross-sectional study, we compared the preoperative MRI treatment response to neoadjuvant chemotherapy (NAC) administration with the postoperative pathological response in breast cancer patients.

Materials And Methods: We analyzed data from 108 hospitalized patients receiving NAC between 2020 and 2022.