Association between interleukin-27 gene polymorphisms and Malaria.

Malaria is often characterized by a complicated disease course due to multifaceted intrinsic genetic factors of the host and the parasite. This study aimed to investigate the role of interleukin-27 () gene polymorphisms in malaria infection in a Saudi Arabian cohort. This case-control study obtained blood samples from 250 malaria patients with and 200 randomly identified healthy control subjects from the Malaria Center in the Jazan area.

Genetic Diversity and Population Genetic Analysis of Thrombospondin Related Anonymous Protein (TRAP) in Clinical Samples from Saudi Arabia.

The thrombospondin related anonymous protein (TRAP) is considered one of the most important pre-erythrocytic vaccine targets. Earlier population genetic studies revealed the gene to be under strong balancing natural selection. This study is the first attempt to analyze genetic diversity, natural selection, phylogeography and population structure in 199 clinical samples from Saudi Arabia using the full-length gene.

Genetic Diversity, Repeat Motifs, and Natural Selection at the C-Terminal Knob-Associated Histidine Rich Protein (KAHRP) of Clinical Samples from Saudi Arabia.

Background: Malaria is still a public health problem in Saudi Arabia specifically in the Jazan region. knob-associated histidine-rich proteins (PfKAHRPs) play an important role in cerebral malaria pathophysiology as well as pathogenesis of infections. The repeat region of PfKAHRP C-terminal interaction domain has been found to bind to the infected red blood cells and the vascular endothelium.

Associations of Single Nucleotide Polymorphisms in IL-18 Gene with -Associated Malaria.

Introduction: Interleukin-18 (IL-18) is a pro-inflammatory cytokine, reported to be involved in the initial immune responses against malaria. Genetic variations in the host are an important factor that influences the etiology of malaria at several disease levels. Polymorphisms within the gene are associated with susceptibility and clinical outcome of several diseases.