Publications by authors named "Ali Khanlarkhani"
Article Synopsis
- A novel antitumor agent, PBPD, was tested on ovarian cancer cell lines to address cisplatin resistance, comparing its effects on both sensitive and resistant cells.
- MTT assays and flow cytometry showed that PBPD was more effective in inducing cell death in cisplatin-sensitive cells, while resistant cells displayed higher IC50 values, suggesting limited effectiveness.
- Gene expression analysis indicated that treatment with PBPD did not significantly increase resistance genes in sensitive cells compared to those treated with cisplatin, positioning PBPD as a potential alternative for overcoming resistance in ovarian cancer.
Background: Bioactive glasses 58S, are silicate-based materials containing calcium and phosphate, which dissolved in body fluid and bond to the bone tissue. This type of bioactive glass is highly biocompatible and has a wide range of clinical applications.
Methods: The 58S glass powders were synthesized via sol-gel methods, using tetraethyl orthosilicate, triethyl phosphate, and calcium nitrate, as precursors.
In recent years, there has been a great interest in using natural polymers in the composition of calcium phosphate bone cements to enhance their physical, mechanical, and biological performance. Gelatin is a partially hydrolyzed form of collagen, a natural component of bone matrix. In this study, the effect of blooming gelatin on the nanohydroxyapatite precipitation, physical and mechanical properties, and cellular responses of a calcium phosphate bone cement (CPC) was investigated.
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