Publications by authors named "Ali Kerem Kalkan"
Article Synopsis
- CHO cells are essential in the biopharmaceutical industry, prompting extensive use of genetic engineering techniques like CRISPR-Cas to enhance their performance in protein production.
- This review highlights recent advances using various CRISPR-Cas systems to improve recombinant protein output in CHO cells while discussing the benefits, limitations, and challenges of these methods.
- Emphasis is placed on how gene regulation affects glycan composition, influencing the properties of therapeutic proteins, and the future potential of CRISPR technology for developing more efficient CHO cell lines, necessitating further research to unlock its full capabilities.
Over the past decades, significant progress has been made in targeted cancer therapy. In precision oncology, molecular profiling of cancer patients enables the use of targeted cancer therapeutics. However, current diagnostic methods for molecular analysis of cancer are costly and require sophisticated equipment.
View Article and Find Full Text PDFThe recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spread all over the world rapidly and caused a global pandemic. To prevent the virus from spreading to more individuals, it is of great importance to identify and isolate infected individuals through testing. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is the gold standard method for the diagnosis of coronavirus disease (COVID-19) worldwide.
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