Publications by authors named "Ali K Khan"
Background: It has been hypothesized that both atrial fibrillation (AF) and medications for AF are poorly tolerated in athletes.
Objective: The purpose of this study was to determine the impact of AF and AF treatments on sports performance.
Methods: An Internet-based survey, initiated via StopAfib.
Article Synopsis
- Connexins (Cx) form gap junction channels (GJCs) by creating hexameric hemichannels that connect adjacent cells, allowing for cell-to-cell communication and independent transport of substances in and out of the cells.
- A mutation (N176Y) was introduced in Cx26, enabling researchers to analyze the structure of these hemichannels using electron cryomicroscopy, revealing an open pore design similar to GJCs.
- The study highlights the importance of the conformational flexibility of extracellular loops in recognizing compatible connexin isoforms for effective intercellular docking, while also linking these findings to past research on the function and properties of connexin hemichannels.
Gap junction channels (GJCs) mediate intercellular communication and are gated by numerous conditions such as pH. The electron cryomicroscopy (cryo-EM) structure of Cx26 GJC at physiological pH recapitulates previous GJC structures in lipid bilayers. At pH 6.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses how combining electron microscopy (EM), X-ray crystallography, and molecular dynamics (MD) simulations can enhance our understanding of complex macromolecular structures and their dynamics.
- It highlights two specific examples: the ribosome and the Arp2/3-actin complex, where these techniques were used to uncover functional dynamics.
- The third example focuses on the GPCR:G protein complex, showcasing how these methods can provide insights into transmembrane signaling, underscoring the advancements in integrative structural biology.
New pH-sensitive lipids were synthesized and utilized in formulations of liposomes suitable for controlled drug release. These liposomes contain various amounts of NaCl in the internal aqueous compartments. The release of the drug model is triggered by an application of HCl cotransporter and exogenous physiologically relevant NaCl solution.
View Article and Find Full Text PDFIn this work, electron paramagnetic resonance (EPR) spectroscopy and X-ray crystallography were used to examine the origins of EPR line shapes from spin-labels at the protein-lipid interface on the β-barrel membrane protein BtuB. Two atomic-resolution structures were obtained for the methanethiosulfonate spin-label derivatized to cysteines on the membrane-facing surface of BtuB. At one of these sites, position 156, the label side chain resides in a pocket formed by neighboring residues; however, it extends from the protein surface and yields a single-component EPR spectrum in the crystal that results primarily from fast rotation about the fourth and fifth bonds linking the spin-label to the protein backbone.
View Article and Find Full Text PDF1-Aminoindanes are generated from allyl diphenylglycinate imines employing a "one-pot" palladium-catalyzed decarboxylative allylation-Heck cyclization cascade. Variation of both the aryl and allyl moieties leads to a diverse range of polycyclic imines, amenable to the synthesis of natural products and other biologically relevant small molecules.
View Article and Find Full Text PDF