Clinical evidence of sesame (Sesamum indicum L.) products and its bioactive compounds on anthropometric measures, blood pressure, glycemic control, inflammatory biomarkers, lipid profile, and oxidative stress parameters in humans: a GRADE-assessed systematic review and dose-response meta-analysis.

This comprehensive systematic review and meta-analysis aimed to assess the impact of sesame (Sesamum indicum L.) supplementation on cardiovascular disease risk factors. Relevant research was discovered via PubMed, Scopus, Web of Science, CENTRAL, and EMBASE up to June 2024.

Effect of Menaquinone-7 (MK-7) Supplementation on Anthropometric Measurements, Glycemic Indices, and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Menaquinone-7 (MK-7) is a type of vitamin K that has a longer half-life and stays in the body for a more extended period compared to other types of vitamin K. Recently, the effects of this vitamin on body weight, glycemic control, and lipid profiles have garnered much attention.

Aim Of The Review: This systematic review and meta-analysis were performed to evaluate the effects of MK-7 on anthropometric measurements, glycemic indices, and lipid profiles.

Beneficial Effects of Okra () Consumption on Anthropometric Measures, Blood Pressure, Glycemic Control, Lipid Profile, and Liver Function Tests in Randomized Controlled Trials: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis.

This review aimed to assess the impact of okra () consumption on cardiovascular disease risk factors. Relevant studies were identified through electronic searches of databases including PubMed, Scopus, Web of Science, CENTRAL, and EMBASE up to January 2025. Twelve trials involving 770 participants with interventions ranging from 2 to 12 weeks and doses varying from 125 to 40,000 mg/day, were included.

Can Coenzyme Q10 Supplementation Reduce Cardiovascular Disease Risk Factors? A Protocol for a GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

Background And Aims: Cardiovascular diseases (CVDs), encompassing a variety of conditions affecting the heart and blood vessels, remain a significant global public health challenge. Among various therapeutic options, Coenzyme Q10 (CoQ10) has garnered attention due to its potential benefits for cardiovascular health. CoQ10 is a naturally occurring antioxidant that plays a crucial role in cellular energy production and has long been used therapeutically.

Health risk assessment via Monte Carlo simulation and sensitivity analysis for fluoride and nitrate content in bottled waters consumed in Kermanshah city, Iran.

Bottled water consumption has increased in recent decade due to many reasons, especially significant decline in water quality and quantity. The concentration of fluoride and nitrate in bottled waters may vary based on brands and locations. This study was carried out to determine the levels of fluoride and nitrate in bottled waters consumed in Kermanshah city and assess the related non -carcinogenic risks.

Using the CIPP Model to elicit perceptions of health professions faculty and students about virtual learning.

Background: The outbreak of the Coronavirus epidemic has caused a huge crisis initiating fundamental changes in education since this crisis has turned face-to-face education into virtual training. This questionnaire-based study employed the comprehensive CIPP Model (Context, Input, Process, Product) to obtain the perspectives of both faculty members and students from six different faculties at one university in Iran concerning implementation of virtual learning in during COVID 19.

Methodology: The participants in this cross-sectional study were 522 students and 38 members of the faculty in six different faculties who were selected via stratified random sampling.

Illuminating the Safety, Tolerability, and Efficacy of Different Ketogenic Diets for Individuals with Epilepsy: A Scoping Meta-Review.

Background: Diet therapies for epilepsy, including the ketogenic diets (KDs), have been used as a treatment for both pediatric and adult populations. Recent studies have focused on the safety, efficacy, and tolerability of various diet therapies for epilepsy. The objective of this scoping meta- review was to evaluate the evidence regarding different ketogenic diets for epilepsy.

A Comprehensive Systematic Review and Meta-Analysis on the Prevalence of Aflatoxin M1 in Dairy Products in Selected Middle East Countries.

Background: Human consumption of dairy products contaminated with aflatoxin (AF) M1 can lead to severe health issues. This AF's significance and impact on health necessitate a thorough investigation of its prevalence in dairy products.

Objectives: This study aims to determine the prevalence of AFM1 in dairy products through a systematic review and meta-analysis, focusing on data from Middle Eastern countries.

Spatial prediction of human brucellosis susceptibility using an explainable optimized adaptive neuro fuzzy inference system.

Brucellosis, a zoonotic disease caused by Brucella bacteria, poses significant risks to human, livestock, and wildlife health, alongside economic losses from livestock morbidity and mortality. This study improves Human Brucellosis Susceptibility Mapping (HBSM) by integrating the Adaptive Neuro-Fuzzy Inference System (ANFIS) with meta-heuristic algorithms, including Genetic Algorithm (GA) and Particle Swarm Optimization (PSO). Boruta-XGBoost identified key covariates, while VIF and tolerance tests addressed collinearity, and Shapley additive explanation (SHAP) values enhanced model interpretability.

Role of dietary patterns in older adults with cognitive disorders: An umbrella review utilizing neuroimaging biomarkers.

Various dietary patterns (DPs) may benefit or harm cognitive status through their components. Publications assessing the impact of DPs on cognitive scores using neuropsychological tests have often led to less promising results. Recently, numerous meta-analyses and systematic reviews have utilized neuroimaging to identify more subtle brain-associated alterations related to cognition.

The Effect of Statin Therapy on Bone Metabolism Markers and Mineral Density: Aa GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

Purpose: Statin therapy is widely used for the management of dyslipidemia and the prevention of cardiovascular diseases (CVDs). However, there is a growing concern about its potential effects on bone metabolism markers and mineral density. The aim of this systematic review and meta-analysis was to investigate the effect of statin therapy on these parameters.

Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials.

The aim of this meta-analysis was to determine the effect of curcumin on a range of health outcomes. PubMed, EMBASE, Scopus, and Web of Science were searched from inception until September 2023. Randomized clinical trials (RCTs) that compared the effect of Curcuma longa L.

Spatial and temporal patterns of urban air pollution in tehran with a focus on PM and associated pollutants.

Understanding the spatial and temporal dynamics of air pollutants is crucial for effective urban air pollution management. This study focuses on the temporal dynamics of air quality monitoring stations (AQMSs) and the association among air pollutants, particularly PM, in Tehran, Iran. Using time series clustering and the Copula model, we analyzed data from 2019 to 2022.

A Systematic Review on Fluoride Contamination in Water Resources of Iran from 2016 to 2023: Spatial Distribution and Probabilistic Risk Assessment (Monte Carlo Simulation).

Because of significant variations and existence of high fluoride (F) in some waters, Iran has been considered for various fluoride studies in recent decades. Nevertheless, there is a no updated review on fluoride levels especially including F risk assessment. Thus, this systematic review is mainly aimed to evaluate the spatial distribution of F content in water sources of Iran using geographic information system (GIS) and conduct the health risk assessment.

Identifying toxic elements in water, sediments, and roots of mangrove forest (Avicennia marina) in Chabahar Bay, Sea of Oman.

Mangroves play a crucial role in filtering pollutants from water and sediments. However, excessive accumulation of potentially toxic elements (PTEs) has harmful effects on marine organisms. This article investigates the concentration and distribution of PTEs in water, sediment, and the roots of endangered mangrove species in Chabahar Bay, a subtropical coastal wetland.

Encapsulation of Candida antarctica lipase B in metal-organic framework under ultrasound and using it to one-pot synthesis of 1,3,4,5-tetrasubstituted pyrazoles.

Encapsulating the enzyme in metal-organic frameworks (MOFs) is a convenient method to prepare MOF-enzyme biocomposite. In this study, Candida antarctica lipase B (CAL-B) was chosen to immobilize in Cu-BTC MOF under ultrasound irradiation. CAL-B was immobilized in Cu-BTC under ultrasound at 21 kHz and 11.

The effect of physical activity intervention on blood pressure in 18 low and middle-income countries: a systematic review and meta-analysis of randomized controlled trials.

Background: In especially, low and middle-income nations (LMICs), where healthcare access may be restricted, high blood pressure (BP) is a major risk factor for cardiovascular disease and stroke, both of which can even lead to death. Altering one's lifestyle, in conjunction with medical therapy, has been demonstrated to be effective in lowering BP. Recent research has shown that physical activity (PA), in a variety of guises and to varying degrees, can be an effective means of lowering BP.

Health risk assessment of heavy metals in the dust street of Mehran city, as a busy city in religious times, Iran.

The concentration of various potentially toxic metals (Pb, Cd, As, Ni, Zn, and Cr) in street dust samples collected from Mehran city, Iran, was analyzed. The samples were obtained during normal traffic conditions, NTT, prior to the Arbaeen ceremony, as well as after the pilgrims' return, which corresponds to high traffic time, HTT. Street dust samples were analyzed for HM content using ICP-OES, following acid digestion.

Ginseng supplementation and cardiovascular disease risk factors: a protocol for GRADE-assessed systematic review and dose-response meta-analysis.

Introduction: Heart diseases constitute a significant global public health concern. Cardiovascular diseases (CVDs) are characterised by disruptions in blood circulation and are notably prevalent among adults exposed to Westernised diets. Ginseng, a medicinal plant, has been recognised for its healing properties and has a history of use spanning thousands of years.

Mechanical properties of human kidney cells and their effects on the atomic force microscope beam vibrations.

In the present investigation, the mechanical properties of normal and carcinomatous cells of kidney tissue (HEK-293, ACHN, respectively) were investigated using atomic force microscopy (AFM). Initially, the elastic modulus of ACHN cells was measured following chemotherapy with the anti-cancer drug Cisplatin and plasma treatment. The MTT assay was employed to ascertain the most effective dosages for incubation periods of 12, 24, 48, 72, and 96 h, guided by the IC concentration for cell viability during chemotherapy treatment.

Empty sella in somatotropic pituitary adenomas; a series of 23 cases.

Purpose: We aimed to investigate empty sella syndrome in somatotrophic pituitary adenoma for possible etiology, complications, and treatment options.

Method: Among over 2,000 skull base masses that have been managed in our center since 2013, we searched for growth hormone-producing adenomas. Clinical, surgical, and imaging data were retrospectively collected from hospital records to check for sella that lacked pituitary tissue on routine imaging.

Enhancing nutrient absorption through the influence of mangrove ecosystem on flow rate and retention time in salt marshes.

This study investigates the impact of pneumatophores (the aerial roots of Avicenna marina) on water flow rate, retention time, contact time, and consequently on nutrient absorption through the sediment in sub-tropical salt marshes. The goal is to realize how the density of mangroves in salt marshes influences the kinematic factors of streamflow at estuaries. To this end, a field experiment was carried out to assess nutrient and organic compound levels in the sediment and water samples, spanning six sampling stations along the Chabahar River discharging to the Chabahar Bay, Iran.