Mediation of Epigenetic Mechanisms in the Regenerative Effect of Uridine in a Rat Model of Sciatic Nerve Injury.

Aim: To investigate the possible mediation of epigenetic mechanisms underlying the regenerative effect of uridine in a sciatic nerve transection rat model.

Material And Methods: Fifty adult male rats were randomized to sham, control, and uridine groups. After unilateral transection and primary anastomosis of the right sciatic nerve, a single daily dose of saline (1 ml/kg; sham and control groups) or uridine (500 mg/kg; uridine group) was injected intraperitoneally for a week.

The association between hematologic parameters and intracranial injuries in pediatric patients with traumatic brain injury.

Objective: Analyzing the association between hematologic parameters and abnormal cranial computerized tomography (CT) findings after head trauma.

Material And Methods: A total of 287 children with isolated traumatic brain injury (TBI) were divided into the 'normal' (NG), 'linear fracture' (LFG) and 'intraparenchymal injury' groups (IPG) based on head CT findings. Demographical/clinical data and laboratory results were obtained from medical records.

Retrospective analysis of decompressive craniectomy performed in pediatric patients with subdural hematoma.

Background: The impact of decompressive craniectomy (DC) on the overall outcome of pediatric acute subdural hematoma patients has not been fully determined to date. In this paper, we aimed to investigate the role of decompressive craniectomy performed to treat traumatic subdural hematoma in patients from the pediatric age group.

Methods: We described our experience with DC in pediatric acute subdural hematoma patients and analyzed the outcomes.