The impact of interrupted ATXN10 expansions on clinical findings of spinocerebellar ataxia type 10.

Background: Spinocerebellar ataxia type 10 (SCA10), due to an ATTCT repeat expansion in ATXN10, has variable expressivity and the role of presence (ATTCTint +) and absence (ATTCTint-) of interruptions in the repeat is not clear. We aimed to describe the relations between ATTCTint + and age at onset, seizures, and neurologic severity in ataxic and non-ataxic carriers from Brazil.

Methods: Family, age at onset (AO), and seizures data plus DNA were obtained from symptomatic carriers already diagnosed in Porto Alegre, Curitiba, and São Paulo, Brazil.

"EpilepSee" Glasses: A Wearable Seizure Prevention Device for Photosensitive Epilepsy.

Temporarily reducing retinal stimulation when exposed to a hazardous photic stimulus by activating a rapidly responding electrochromic material could provide a novel seizure prevention method, referred to as the "EpilepSee Glasses", for people with photosensitive epilepsy.Analysis of an electroencephalogram (EEG) recording has shown reduced photoparoxysmal responses when exposed to flashing light whilst wearing a pair of glasses with one lens covered by an electrochromic material. By characterising the variation of the light seen in a user's field of vision in real time, and exploiting the fact that a stimulus must, on average, be present for at least 1 second to cause a seizure, the glasses' lens only needs to activate upon detection of a potentially harmful stimulus.

Botanical sources, biopharmaceutical profile, anticancer effects with mechanistic insight, toxicological and clinical evidence of prunetin: a literature review.

Prunetin (PRU), a naturally occurring flavonoid, has gained recognition for its wide-ranging therapeutic benefits, though its anticancer properties have yet to be extensively reviewed. This study explores the potential of PRU in targeting critical molecular pathways involved in tumor progression, including oxidative stress, apoptosis, cell cycle regulation, and metastasis. Data were compiled from reputable sources, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar.

Machine learning classification of active viewing of pain and non-pain images using EEG does not exceed chance in external validation samples.

Previous research has demonstrated that machine learning (ML) could not effectively decode passive observation of neutral versus pain photographs by using electroencephalogram (EEG) data. Consequently, the present study explored whether active viewing, i.e.

Case series: Using laryngeal mask airway to enhance the radiological evaluation and staging of cancers involving the larynx: A novel technique.

The diagnosis and staging of head and neck tumors requires proper clinical, endoscopic, and radiological evaluation. Currently, imaging techniques such as Magnetic Resonance Imagining (MRI) and Computed Tomography (CT) are used for head and neck tumors but are limited in showing involvement of different hypopharyngeal sub-compartments. Several maneuvers have been developed to improve visualization of the head and neck area; however, they demonstrated minimal benefit.

Risk factors associated with human echinococcosis: a systematic review and meta-analysis.

Introduction: Echinococcosis is a widespread zoonotic disease caused by tapeworms of the Echinococcus genus, manifesting in mature or larval forms. Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are the primary types affecting humans, linked, respectively, to and . This study is a systematic review and meta-analysis of the risk factors associated with CE and AE in humans.

Presentation and management of pancreatic hydatid cyst: A comprehensive systematic review of the literature with meta-data.

Introduction: Hydatid cysts are among many cysts that can develop in the pancreas. Both the size and location of these cysts significantly influence clinical presentation and surgical approach required for management. This study aims to review the literature concerning pancreatic hydatic cysts, their presentations, and management strategies.

Middle-grade led Expedited Gall bladder lists: Is it safe and feasible?

Introduction: Gallstone-related acute admissions account for a significant percentage of acute general surgery admissions. Providing a dedicated expedited gall bladder list service to deal with these cases appears to be not only clinically effective but also cost-effective. There are various logistical reasons why hospitals are unable to provide such dedicated lists, inadequate surgical staff being one of them.

Zinc-based fixative as a novel approach for histological preservation: A comparative study with formalin-based fixatives.

Background: Formalin is a widely used histological fixative despite its carcinogenic properties, inadequate nucleic acid preservation, and prolonged fixation time.

Aim: The study intended to prepare a novel zinc-based fixative that is, formalin-free, and cost-effective, provides optimal preservation, with rapid penetration rates, and enhanced Hematoxylin/Eosin-stained sections.

Methods: Liver, kidney, brain, and small intestine specimens were collected from 10 adult laboratory rats () and preserved in formalin 4%, formalin 10%, neutral buffered formalin (NBF), and the experimental EZAT solution.

Chlamydia infection with vaccination asymptotic for qualitative and chaotic analysis using the generalized fractal fractional operator.

In this work, we solve a system of fractional differential equations utilizing a Mittag-Leffler type kernel through a fractal fractional operator with two fractal and fractional orders. A six-chamber model with a single source of chlamydia is studied using the concept of fractal fractional derivatives with nonsingular and nonlocal fading memory. The fractal fractional model of the Chlamydia system can be solved by using the characteristics of a non-decreasing and compact mapping.

W. Attenuates Inflammation and Oxidative Stress in Freund's Complete Adjuvant-Induced Rheumatoid Arthritis in Wistar Rats.

Rheumatoid arthritis (RA) is an autoimmune disease that causes distinctive inflammatory symptoms and affects over 21 million people worldwide. RA is characterized by severe discomfort, swelling, and degradation of the bone and cartilage, further impairing joint function. The current study investigates the antiarthritic effect of a methanolic extract of (methanolic extract of , MEAP), an aromatic herb.

Immunotherapy for Parkinson's Disease and Alzheimer's Disease: A Promising Disease-Modifying Therapy.

Alzheimer's disease (AD) and Parkinson's disease (PD) are two neurodegenerative diseases posing a significant disease burden due to their increasing prevalence and socio-economic cost. Traditional therapeutic approaches for these diseases exist but provide limited symptomatic relief without addressing the underlying pathologies. This review examines the potential of immunotherapy, specifically monoclonal antibodies (mAbs), as disease-modifying treatments for AD and PD.

Computational techniques to monitoring fractional order type-1 diabetes mellitus model for feedback design of artificial pancreas.

Background And Objectives: In this paper, we developed a significant class of control issues regulated by nonlinear fractal order systems with input and output signals, our goal is to design a direct transcription method with impulsive instant order. Recent advances in the artificial pancreas system provide an emerging treatment option for type 1 diabetes. The performance of the blood glucose regulation directly relies on the accuracy of the glucose-insulin modeling.

Formulation of Phytosomes Containing Extract for Neuropathic Pain: and Evaluation.

This study aimed to develop a delivery system for the dried aqueous extract of leaves (RCE) that could improve the neuroprotective potential of RCE by improving the bioavailability of the chief chemical constituent rubiadin. Rubiadin, an anthraquinone chemically, is a biomarker phytoconstituent of RCE. Rubiadin is reported to have strong antioxidant and neuroprotective activity but demonstrates poor bioavailability.

Physiological and chaos effect on dynamics of neurological disorder with memory effect of fractional operator: A mathematical study.

Background And Objective: To study the dynamical system, it is necessary to formulate the mathematical model to understand the dynamics of various diseases that are spread worldwide. The main objective of our work is to examine neurological disorders by early detection and treatment by taking asymptomatic. The central nervous system (CNS) is impacted by the prevalent neurological condition known as multiple sclerosis (MS), which can result in lesions that spread across time and place.

Early Diagnosis of Cardiovascular Diseases in the Era of Artificial Intelligence: An In-Depth Review.

Cardiovascular diseases (CVDs) are significant health issues that result in high death rates globally. Early detection of cardiovascular events may lower the occurrence of acute myocardial infarction and reduce death rates in people with CVDs. Traditional data analysis is inadequate for managing multidimensional data related to the risk prediction of CVDs, heart attacks, medical image interpretations, therapeutic decision-making, and disease prognosis due to the complex pathological mechanisms and multiple factors involved.

Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice.

Fatty acids, particularly omega-3, omega-6, and omega-9, play a vital role in various biological processes. As the body cannot synthesize omega-3 and omega-6, dietary sources of these fatty acids are essential. Each omega fatty acid has a distinct chemical structure, source, and function.

Clinical performance of custom-milled polyetherketoneketone (PEKK) posts and cores: A 12-month follow-up randomized controlled pilot study.

Objectives: Comparing the survival rate and the cumulative success rates of custom-milled polyetherketone ketone posts and cores (MPP) with prefabricated fiber posts (PFP) in restoring compromised endodontically treated premolars.

Material And Methods: This was a randomized, double-blind, parallel, two-arm controlled pilot study. A total of 24 patients (12 males, 12 females), each had a compromised lower premolar, needed a root canal treatment and to be restored with post and core.

Unleashing the potential of vanillic acid: A new twist on nature's recipe to fight inflammation and circumvent azole-resistant fungal infections.

Vanillic acid (VA) - a naturally occurring phenolic compound in plants - is not only used as a flavoring agent but also a prominent metabolite post tea consumption. VA and its associated compounds are believed to play a significant role in preventing diseases, underscoring the need for a systematic investigation. Herein, we report a 4-step synthesis employing the classical organic reactions, such as Willamson's alkylation, Fischer-Spier reaction, and Steglich esterification, complemented with a protection-deprotection strategy to prepare 46 VA derivatives across the five series (1a-1i, 2a-2i, 3, 3a-3i, 4a-4i, 5a-5i) in high yields.

Response Surface Methodology (RSM) approach to formulate and optimize the bilayer combination tablet of Tamsulosin and Finasteride.

An orally administered bilayer tablet with Tamsulosin (TAM) as the sustained release (SR) and Finasteride (FIN) as immediate release (IR) was manufactured. A response surface methodology was employed to formulate bilayer tablets with individual release layers, i.e.

Effect of Low-Level Lasers on Total Bilirubin Concentration in Human Blood Plasma Using 375 and 650 nm Lasers.

The current research extends previous laboratory investigations by investigating the effects of low-level laser irradiation (LLLI) on human blood plasma. Total bilirubin is of special importance because of its potential biostimulatory and modulatory actions. This study aims to analyze changes in total bilirubin content as a consequence of LLLI on human blood plasma.

Histotoxicity induced by copper oxide nanoparticles (CuO-NPs) on developing mice (Mus musculus).

The wide range of applications of nanoparticles (NPs) in various industries have led to serious consequences in terms of teratogenic toxicity. The aim of current work was to evaluate the teratogenic effects of copper oxide (CuO) nanoparticles in albino mice.In this experimental study, after mating, inseminated 40 female mice were divided randomly into 4 pools (1 control and 3 experimental), ten each.

Myopia prevalence and risk factors among medical trainees in Lebanon.

Purpose: Myopia is known to be one of the most common causes of impaired vision. It is on the rise, especially among high-risk groups such as medical students. Our study aims to estimate the prevalence of myopia and characterize the associated risk factors among medical trainees in Lebanon.