Publications by authors named "Ali Haidar"

Purpose: We aimed to characterize genomic alterations with potential prognostic or predictive significance in patients with metastatic triple-negative breast cancer (mTNBC) treated with chemotherapy in a real-world setting.

Patients And Methods: Next-generation sequencing with FoundationOne® CDx was conducted primarily on primary tumor tissue from 112 consecutive patients with mTNBC. Genomic alterations were subdivided into canonical oncogenic pathways and noted for their involvement in homologous recombination deficiency (HRD).

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Article Synopsis
  • Dengue virus, transmitted primarily by Aedes mosquitoes, poses a major health risk in tropical areas and consists of four serotypes, with DENV-2 identified as the most prevalent in recent studies from Pakistan (2023-2024).
  • Research involved analyzing serum samples to identify serotypes and characterized the envelope gene using techniques like nested PCR and sequencing, revealing DENV-2's close relation to strains in China and India.
  • The study suggests potential antiviral compounds, specifically Arbidol and Quercetin, and identifies B-cell epitopes for future vaccine development, aiming to improve dengue management strategies in the region.
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To report a case of polypoidal choroidal vasculopathy (PCV) recalcitrant to treatment with ranibizumab and with a ranibizumab port delivery system (Susvimo) but responsive to faricimab-svoa. A case and its findings were analyzed. A 69-year-old Filipino man with PCV in the left eye was treated for 2 years with multiple ranibizumab intravitreal (IVT) injections followed by ranibizumab port delivery combined with rescue ranibizumab IVT injections, with no significant response clinically or on imaging.

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Background: Early preterm infants are susceptible to a serious disorder called intraventricular hemorrhage (IVH), which may cause severe neurological damage.

Objective: To determine the incidence of IVH in preterm infants at Lady Reading Hospital, Peshawar, Pakistan, and to identify associated risk factors and potential preventive measures.

Methodology: This cross-sectional research examined the prevalence of IVH among early preterm infants and was carried out at Lady Reading Hospital in Peshawar from 1 January 2021 to 31 December 2023.

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Soil salinization is a critical global issue for sustainable agriculture, impacting crop yields and posing a threat to achieving the Sustainable Development Goal (SDG) of ensuring food security. It is necessary to monitor it in detail and uncover its underlying factors at a regional scale. In this context, the present study aimed to evaluate soil health in the eastern Mediterranean region by using the Sodium Adsorption Ratio (SAR) as an indicator of soil salinity in three distinct soil horizons.

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Most RNA-protein condensates are composed of heterogeneous immiscible phases. However, how this multiphase organization contributes to their biological functions remains largely unexplored. Drosophila germ granules, a class of RNA-protein condensates, are the site of mRNA storage and translational activation.

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Software-Defined Networking (SDN) revolutionizes network management by decoupling control plane functionality from data plane devices, enabling the centralized control and programmability of network behavior. This paper uses the ternary system to improve the Central Processing Unit (CPU) inside the SDN controller to enhance network management. The Multiple-Valued Logic (MVL) circuit shows remarkable improvement compared to the binary circuit regarding the chip area, propagation delay, and energy consumption.

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Questions about the origin of the adsorption/desorption hysteresis in mesoporous materials are as old as sorption experiments themselves. The historical conception that underlines most existing methods to extract pore size distributions from sorption data assumes that adsorption is a metastable process and that desorption takes place at thermodynamic equilibrium. In this work, we measure nitrogen and argon sorption on a series of 14 SBA-15 ordered mesoporous silicas and use small-angle X-ray scattering to independently determine their pore sizes.

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Spontaneous urinoma is a rare urological complication that can occur following acute urinary obstruction. It involves a collection of urine that typically forms around the kidney as a result of rupture of the fornix. There are several causes of acute urinary stasis, including lithiasis, tumors, prostatic hypertrophy, and others.

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Article Synopsis
  • The article explores the importance of Dominating David-derived networks, particularly their fractal nature, which has applications in fields like topology, chemistry, and computer science.
  • It aims to create closed-form formulas for eccentricity-based descriptors related to these networks, which can provide insights into thermodynamic and physicochemical properties of molecules.
  • By calculating indices like total eccentricity and the Zagreb index for a specific type of this network (D2(m)), the findings enhance the understanding of complex chemical structures and their biological activities.
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The design of the Ternary Full Adders (TFA) employing Carbon Nanotube Field-Effect Transistors (CNFET) has been widely presented in the literature. To obtain the optimal design of these ternary adders, we propose two new different designs, TFA1 with 59 CNFETs and TFA2 with 55 CNFETs, that use unary operator gates with two voltage supplies (Vdd and Vdd/2) to reduce the transistor count and energy consumption. In addition, this paper proposes two 4-trit Ripple Carry Adders (RCA) based on the two proposed TFA1 and TFA2; we use the HSPICE simulator and 32 nm CNFET to simulate the proposed circuits under different voltages, temperatures, and output loads.

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Multiple outcome prediction models have been developed for Head and Neck Squamous Cell Carcinoma (HNSCC). This systematic review aimed to identify HNSCC outcome prediction model studies, assess their methodological quality and identify those with potential utility for clinical practice. Inclusion criteria were mucosal HNSCC prognostic prediction model studies (development or validation) incorporating clinically available variables accessible at time of treatment decision making and predicting tumour-related outcomes.

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Radiotherapy for thoracic and breast tumours is associated with a range of cardiotoxicities. Emerging evidence suggests cardiac substructure doses may be more predictive of specific outcomes, however, quantitative data necessary to develop clinical planning constraints is lacking. Retrospective analysis of patient data is required, which relies on accurate segmentation of cardiac substructures.

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In progressing the use of big data in health systems, standardised nomenclature is required to enable data pooling and analyses. In many radiotherapy planning systems and their data archives, target volumes (TV) and organ-at-risk (OAR) structure nomenclature has not been standardised. Machine learning (ML) has been utilised to standardise volumes nomenclature in retrospective datasets.

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A branch of graph theory that makes use of a molecular graph is called chemical graph theory. Chemical graph theory is used to depict a chemical molecule. A graph is connected if there is an edge between every pair of vertices.

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Chemical descriptors are numeric numbers that capture the whole graph structure and comprise a basic chemical structure. As a topological descriptor, it correlates with certain physical aspects in addition to its chemical representation of underlying chemical substances. In the modelling and design of any chemical network, the graph is important.

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The proteome represents all the proteins expressed by a genome, a cell, a tissue, or an organism at any given time under defined physiological or pathological circumstances. Proteomic analysis has provided unparalleled opportunities for the discovery of expression patterns of proteins in a biological system, yielding precise and inclusive data about the system. Advances in the proteomics field opened the door to wider knowledge of the mechanisms underlying various post-translational modifications (PTMs) of proteins, including glycosylation.

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Endophytic bacteria have been utilized as an alternative source to chemical fertilizers and pesticides to enhance plant productivity and defense mechanisms against biotic and abiotic stress. Five endophytic bacterial strains were isolated from the seeds of three different Pakistani wheat varieties (Ghaneemat-e-IBGE, Atta-Habib, and Siren). The isolated strains AH-1, S-5, S-7, GI-1, and GI-6 showed phylogenetic similarity with , , , , and , respectively.

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As non-renewable natural resources, restoring Syrian soil quality is a vital issue for sustainable future planning after conflict ends. The data provided in this research exhibit features and physiochemical properties for soils from the southern part of Syria until the Jordanian border, which can provide decision-makers with sufficient information for rehabilitation stage after conflict in a regional scale. The data were collected from 107 representative soil profiles covering diverse agroecosystems throughout the area (i.

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is a genus of small, veil-less coprinoid mushrooms in the family Psathyrellaceae (Agaricales). The genus is not well documented in Asia, specifically in Pakistan. In this study we describe two new species and from Pakistan, based on morphological and molecular data.

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In biology field, the ontology application relates to a large amount of genetic information and chemical information of molecular structure, which makes knowledge of ontology concepts convey much information. Therefore, in mathematical notation, the dimension of vector which corresponds to the ontology concept is often very large, and thus improves the higher requirements of ontology algorithm. Under this background, we consider the designing of ontology sparse vector algorithm and application in biology.

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Background: Over past few decades, the expectations of medical students about their academics, extracurricular support from college and about their social life at campus have all been changed greatly. The relative scarcity of data about the expectations of Pakistani medical students has merited this study.

Method: A cross-sectional survey was undertaken at Ayub Medical College, Abbottabad at the in December, 2012 based on random sampling technique.

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We present applications of audited credential delegation (ACD), a usable security solution for authentication, authorization and auditing in distributed virtual physiological human (VPH) project environments that removes the use of digital certificates from end-users' experience. Current security solutions are based on public key infrastructure (PKI). While PKI offers strong security for VPH projects, it suffers from serious usability shortcomings in terms of end-user acquisition and management of credentials which deter scientists from exploiting distributed VPH environments.

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Usability is an all too often neglected aspect of grid computing, although it is one of the principal factors militating against the widespread uptake of distributed computing. Many resource providers on a grid infrastructure deploy a standard middleware stack and expect users to invoke the default client tools for that middleware stack to access their resources. Unfortunately, many of these middleware client tools have been developed as an afterthought, and are widely considered difficult to use.

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Objective: The use of bisphosphonates (zoledronic acid) in the treatment of metastatic bone disease has been raised during recent years. The purpose of this treatment is mainly to reduce skeletal-related events, e.g.

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