Combined effect of age and body mass index on postoperative mortality and morbidity in laparoscopic cholecystectomy patients.

Background: Previous studies have assessed the impact of age and body mass index (BMI) on surgery outcomes separately. This retrospective cohort study aimed to investigate the combined effect of age and BMI on postoperative mortality and morbidity in patients undergoing laparoscopic cholecystectomy.

Methods: Data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database for laparoscopic cholecystectomy patients between 2008 and 2020 were analyzed.

Identification of the novel HLA-C*04:495 allele by sequencing-based typing.

The HLA-C*04:495 allele differs from HLA-C*04:01:01:31 by two nucleotide changes in the 5'UTR and exon 5.

Age/BMI is a Stronger Predictor of Death in COVID-19 Patients than Age Alone: A Pilot Study.

The objective of this study was to investigate the effect of age and BMI on the risk of death in patients with coronavirus disease 2019 (COVID-19). A cohort of 206 Saudi COVID-19 patients was included in this study. Data on age, BMI, hospitalization, comorbidities, and death were collected and analyzed.

Identification of the novel HLA-A*74:03:03 allele by sequencing-based typing.

HLA-A*74:03:03 differs from A*74:03:01 by a synonymous mutation at nucleotide 1948 in exon 4.

Identification of the novel HLA-DQB1*03:483 allele by sequencing-based typing.

A single nucleotide change in exon 1 of HLA-DQB1*03:01:01:03 results in the novel HLA-DQB1*03:483 allele.

Kinetics of antibody response in critically ill patients with Middle East respiratory syndrome and association with mortality and viral clearance.

The objective of this study is to examine the IgG antibody response in critically ill patients with the Middle East respiratory syndrome (MERS) and to examine the association of early antibody response with mortality and viral clearance. We collected blood samples from 40 consecutive real-time reverse transcription-polymerase chain reaction (rRT-PCR) confirmed critically ill MERS patients on ICU days 1, 3, 7, 14 and 28. MERS-CoV antibodies were detected by enzyme-linked immunosorbent assay (ELISA), using wells coated with MERS-CoV S1 antigen.

Characterization of the novel HLA-B*57:02:01:03 allele by sequencing-based typing.

Two-nucleotide changes in the 3' UTR of HLA-B*57:02:01:01 result in the novel HLA-B*57:02:01:03 allele.

Characterization of the novel HLA-A*68:277 allele by sequencing-based typing.

A single nucleotide change in exon 1 of HLA-A*68:01:01:02 results in the novel HLA-A*68:277 allele.

Characterization of the novel HLA-A*31:199 allele by sequencing-based typing.

A single nucleotide change in exon 4 of HLA-A*31:01:02:31 results in the novel HLA-A*31:199 allele.

Identification of a novel HLA-B*18 variant, HLA-B*18:01:01:52, in a Saudi individual.

A single nucleotide change in the 3' UTR of HLA-B*18:01:01:01 results in the novel HLA-B*18:01:01:52 allele.

Identification of a novel HLA-A*31 variant, HLA-A*31:01:02:31, in a Saudi individual.

A single nucleotide change in the 5' UTR of A*31:01:02:01 results in the novel HLA-A*31:01:02:31 allele.

Inflammatory Response and Phenotyping in Severe Acute Respiratory Infection From the Middle East Respiratory Syndrome Coronavirus and Other Etiologies.

Objectives: In this study, we evaluated the inflammatory response in patients with severe acute respiratory infection due to the Middle East respiratory syndrome and non-Middle East respiratory syndrome and assessed the presence of distinct inflammatory subphenotypes using latent class analysis.

Design: Prospective cohort study.

Setting: A tertiary care ICU in Riyadh, Saudi Arabia.

The novel HLA-DQB1*06:03:01:06 allele identified in a Saudi individual.

HLA-DQB1*06:03:01:06 differs from HLA-DQB1*06:03:01:01 by a single nucleotide substitution in intron 2.

Novel HLA-B*81:02:02 allele identified in a Saudi individual.

HLA-B*81:02:02 differs from HLA-B*81:02 by a synonymous substitution in exon 5.

Novel HLA-B*50:66 allele, identified by next-generation sequencing in a Saudi individual.

HLA-B*50:66 differs from HLA-B*50:01:01:01 by a single nucleotide substitution (C>A) in codon 153.

Novel HLA-DPB1*10:01:05 allele, identified by next-generation sequencing in a Saudi individual.

HLA-DPB1*10:01:05 differs from HLA-DPB1*10:01:01:01 by a single synonymous nucleotide substitution in exon 2, 38 G>A.

Novel HLA-C*06:284 allele, identified by next-generation sequencing in a Saudi individual.

HLA-C*06:284 differs from HLA-C*06:02:01:02 by two single nucleotide substitutions in codon 24 (Ser > Thr).

Novel HLA-DPB1*14:01:11 allele, identified by next-generation sequencing in a Saudi individual.

HLA-DPB1*14:01:11 differs from HLA-DPB1*14:01:01:01 by a single synonymous nucleotide substitution in codon 52.

The novel HLA-A*68:227 allele, identified by Next-Generation Sequencing in a Saudi individual.

HLA-A*68:227 differs from HLA-A*68:84 by two single nucleotide substitutions in codon 10 and 90.

The novel HLA-DRB3*03:39 allele, identified by next-generation sequencing in a Saudi individual.

HLA-DRB3*03:39 differs from HLA-DRB3*03:01:01 by a single nucleotide substitution in codon 22 (Glutamic acid to Lysine).

The novel HLA-B*07:387 allele, identified by next-generation sequencing in a Saudi individual.

HLA-B*07:387 differs from HLA-B*07:05:01:01 by a single nucleotide substitution in codon 91 (Glycine to Tryptophan).

The novel HLA-DRB1*13:290 allele, identified by next-generation sequencing in a Saudi individual.

HLA-DRB1*13:290 differs from HLA-DRB1*13:02:01:01 by a single nucleotide substitution in codon 86 (Gly > Ala).