A review of computational optimization of bone scaffold architecture: methods, challenges, and perspectives.

The design and optimization of bone scaffolds are critical for the success of bone tissue engineering (BTE) applications. This review paper provides a comprehensive analysis of computational optimization methods for bone scaffold architecture, focusing on the balance between mechanical stability, biological compatibility, and manufacturability. Finite element method (FEM), computational fluid dynamics (CFD), and various optimization algorithms are discussed for their roles in simulating and refining scaffold designs.

Understanding compressive viscoelastic properties of additively manufactured PLA for bone-mimetic scaffold design.

Bone tissue engineering has been recognized as a promising strategy to repair or replace damaged bone tissues. The mechanical properties of bone scaffolds play a critical role in successful bone regeneration, as it is essential to match the mechanical properties of the scaffold with the surrounding bone tissue. In this study, we investigated the effects of fused deposition modeling (FDM) process parameters, including printing speed, printing temperature, and layer thickness, on the compressive viscoelastic properties of polylactic acid (PLA) scaffolds.

Multi-objective Shape Optimization of Bone Scaffolds: Enhancement of Mechanical Properties and Permeability.

Porous scaffolds have recently attracted attention in bone tissue engineering. The implanted scaffolds are supposed to satisfy the mechanical and biological requirements. In this study, two porous structures named MFCC-1 (modified face centered cubic-1) and MFCC-2 (modified face centered cubic-2) are introduced.

Shape optimization of orthopedic porous scaffolds to enhance mechanical performance.

Polymeric bone scaffolds are supposed to temporarily bear the external mechanical forces applied to the injured area. The implanted scaffolds should satisfy both mechanical and cell-proliferation requirements. In this study, to design an optimum scaffold structure from mechanical and cell growth perspectives, a new scaffold structure named MFCC (Modified Face Centered Cubic) is introduced, which is based on the Face Centered Cubic (FCC) arrangement of spherical pores.

Effect of collagen degradation on the mechanical behavior and wrinkling of skin.

Chronological skin aging is a complex process that is controlled by numerous intrinsic and extrinsic factors. One major factor is the gradual degradation of the dermal collagen fiber network. As a step toward understanding the mechanistic importance of dermal tissue in the process of aging, this study employs analytical and multiscale computational models to elucidate the effect of collagen fiber bundle disintegration on the mechanical properties and topography of skin.