Publications by authors named "Ali H Amin"

Purpose: Co-administration of microRNAs and chemotherapy drugs effectively treats several cancers. The current study sought to investigate the function of matrix metalloproteinase 16 (MMP16) and miR-193a-5p in the pathogenesis of gastric cancer (GC).

Materials/methods: Sixty-five surgical patients, 15 receiving 5-fluorouracil (5-FU), provided GC and adjacent non-cancerous tissue.

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Article Synopsis
  • The article DOI: 10.3389/fimmu.2023.1127358 has been revised.
  • The corrections address specific inaccuracies or errors in the original publication.
  • Updated findings or data may alter conclusions drawn in prior versions.
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Angiotensin-converting enzyme 2 (ACE2) is identified as the functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the ongoing global coronavirus disease-2019 (COVID-19) pandemic. This study aimed to elucidate potential therapeutic avenues by scrutinizing approved drugs through the identification of the genetic signature associated with SARS-CoV-2 infection in individuals with asthma. This exploration was conducted through an integrated analysis, encompassing interaction networks between the ACE2 receptor and common host (co-host) factors implicated in COVID-19/asthma comorbidity.

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Colorectal cancer (CRC) is one of the main causes of cancer-related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer-related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years.

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Keratin 7 (KRT7), also known as cytokeratin-7 (CK-7) or K7, constitutes the principal constituent of the intermediate filament cytoskeleton and is primarily expressed in the simple epithelia lining the cavities of the internal organs, glandular ducts, and blood vessels. Various pathological conditions, including cancer, have been linked to the abnormal expression of KRT7. KRT7 overexpression promotes tumor progression and metastasis in different human cancers, although the mechanisms of these processes caused by KRT7 have yet to be established.

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Aims: Cognitive impairment poses a considerable health challenge in the context of type 2 diabetes mellitus (T2DM), emphasizing the need for effective interventions. This study delves into the therapeutic efficacy of quercetin, a natural flavonoid, in mitigating cognitive impairment induced by T2DM in murine models.

Materials And Methods: Serum exosome samples were obtained from both T2DM-related and healthy mice for transcriptome sequencing, enabling the identification of differentially expressed mRNAs and long noncoding RNAs (lncRNAs).

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A severe global health concern is the rising incidence and mortality rate of colorectal cancer (CRC). Chemotherapy, which is typically used to treat CRC, is known to have limited specificity and can have noticeable side effects. A paradigm shift in cancer treatment has been brought about by the development of targeted therapies, which has led to the appearance of pharmacological agents with improved efficacy and decreased toxicity.

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Oligospermia and asthenozoospermia, both frequent, can lead to male infertility. Oligospermia might be viewed as a milder form of azoospermia because the same mutations that produce azoospermia in some individuals also create oligospermia in other individuals. In this, we looked at different characteristics of oligospermia men, counting the level of apoptosis and a few related apoptotic and oxidative stress components, and compared them to solid controls.

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The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers for medicinal purposes have been approved for human trials, only a few have been authorized for clinical use in targeting cancer cells.

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Aims: Pain is a profoundly debilitating symptom in cancer patients, leading to disability, immobility, and a marked decline in their quality of life. This study aimed to investigate the potential roles of miR-199a-3p in a murine model of bone cancer pain induced by tumor cell implantation in the medullary cavity of the femur.

Materials And Methods: We assessed pain-related behaviors, including the paw withdrawal mechanical threshold (PWMT) and the number of spontaneous flinches (NSF).

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Article Synopsis
  • - T helper (Th) 17 cells are crucial in combating infections and are involved in autoimmune diseases and chronic inflammation.
  • - Long non-coding RNAs (lncRNAs) play significant roles in regulating gene expression and are linked to various biological processes important for immune cell function.
  • - The article explores recent research on how lncRNAs influence Th17 cell differentiation across several health issues, including autoimmune diseases, cancer, asthma, heart disease, and infections.
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Aims: Retinal ischemia/reperfusion (I/R) injury is a common pathological basis for various ophthalmic diseases. This study aimed to investigate the potential of sulforaphane (SFN) and Homer1a in regulating cell apoptosis induced by retinal I/R injury and to explore the underlying regulatory mechanism between them.

Materials And Methods: In in vivo experiments, C57BL/6J mice and Homer1/Homer1a/Nestin-Cre mice were used to construct retinal I/R injury models.

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In the entire world, prostate cancer (PCa) is one of the most common and deadly cancers. Treatment failure is still common among patients, despite PCa diagnosis and treatment improvements. Inadequate early diagnostic markers and the emergence of resistance to conventional therapeutic approaches, particularly androgen-deprivation therapy, are the causes of this.

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Autoimmune diseases are complex, chronic inflammatory conditions initiated by the loss of immunological tolerance to self-antigens. Nowadays, there is no effective and useful therapy for autoimmune diseases, and the existing medications have some limitations due to their nonspecific targets and side effects. During the last few decades, it has been established that mesenchymal stem cells (MSCs) have immunomodulatory functions.

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  • Mesenchymal stem cells (MSC) might help treat eye diseases because they can change into different cell types and help control immune responses.
  • These cells release special substances that can change how immune cells work, which is important in reducing inflammation in the eyes.
  • MSCs can also produce tiny particles called exosomes that carry beneficial components and can reach the eye without harming other cells, making them a safe treatment option.
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  • * It highlights the effectiveness of bioresponsive nanocarriers that can deliver drugs and genes directly to PC cells, enhancing drug accumulation and promoting tumor suppression while minimizing side effects on normal cells.
  • * Additionally, it introduces phototherapy as a new cancer treatment method that works alongside traditional therapies, utilizing nanoparticles to trigger cell death and improve targeting for better outcomes in managing pancreatic cancer.
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UV and solar-based photocatalytic degradation of 2,4-dichlorophenol (2,4-DCP) as an organic contaminant in ceramics industry wastewater by ZnS and Fe-doped ZnS NPs was the focus of this research. Nanoparticles were prepared using a chemical precipitation process. The cubic, closed-packed structure of undoped ZnS and Fe-doped ZnS NPs was formed in spherical clusters, according to XRD and SEM investigations.

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The current research concentrated on the Co-precipitation synthesis of g-CN (CN), ZnO, ZnO/CN, and Co-doped ZnO/CN nanocomposite, as well as the solar light enhanced photocatalytic treatment of Reactive Red 120 (RR120) from genuine wool textile effluent. The 3D flower-like structure of Co-doped ZnO distributed on the surface of CN thin sheets, according to structural studies employing XRD and SEM examinations Electrochemical experiments exhibited that the Co-doped ZnO/CN nanocomposite has a large electroactive surface area. The optical band-gap values of CN, ZnO, ZnO/CN, and Co-doped ZnO/CN nanocomposites were 2.

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  • * Mesenchymal stem/stromal cell (MSC) therapy shows promise for enhancing wound healing due to their capacity to multiply, differentiate, and their favorable properties like low tumor risk and immune compatibility.
  • * Extracellular vesicles (EVs), produced by MSCs, serve as a potential alternative to stem cell therapies, offering benefits like reduced immune reactions and easier handling, and are increasingly explored for their therapeutic roles in skin wound healing.
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  • Melanoma is a highly aggressive skin cancer that is more treatable when caught early, but survival rates drop significantly once it advances to metastatic stages.
  • Immunotherapy has shown potential by boosting anti-tumor responses, but clinical results have been mixed, partly due to the influence of regulatory T (Treg) cells that help tumors evade immune attacks.
  • This review aims to analyze how Treg cells contribute to melanoma progression and explore strategies to effectively target these cells to improve treatment outcomes.
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Recurrent pregnancy loss (RPL) occurs in approximately 5% of women. Despite an abundance of evidence, the molecular mechanism of RPL's pathology remains unclear. Here, we report the protective role of polo-like kinase 1 (PLK1) during RPL.

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Kidney has a crucial role in immunity, so any toxicity occurs for the kidney will result in reduced immunity. The aim of this study is to improve the immune response of insufficient kidneys through immune-related genes. Diethyl Nitrosamine has been used to cause kidney damage in animal models, vitamin C and curcumin have been used to treat impaired kidney.

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CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors (GPCRs) superfamily and is specific for CXC chemokine ligand 12 (CXCL12, also known as SDF-1), which makes CXCL12/CXCR4 axis. CXCR4 interacts with its ligand, triggering downstream signaling pathways that influence cell proliferation chemotaxis, migration, and gene expression. The interaction also regulates physiological processes, including hematopoiesis, organogenesis, and tissue repair.

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