Enhancing classification of active and non-active lesions in multiple sclerosis: machine learning models and feature selection techniques.

Introduction: Gadolinium-based T1-weighted MRI sequence is the gold standard for the detection of active multiple sclerosis (MS) lesions. The performance of machine learning (ML) and deep learning (DL) models in the classification of active and non-active MS lesions from the T2-weighted MRI images has been investigated in this study.

Methods: 107 Features of 75 active and 100 non-active MS lesions were extracted by using SegmentEditor and Radiomics modules of 3D slicer software.

The use of nanocarriers in treating Batten disease: A systematic review.

The neuronal ceroid lipofuscinoses, commonly known as Batten disease, are a group of lysosomal storage disorders affecting children. There is extensive central nervous system and retinal degeneration, resulting in seizures, vision loss and a progressive cognitive and motor decline. Enzyme replacement and gene therapies are being developed, and mRNA and oligonucleotide therapies are more recently being considered.

Examining cardiac toxicity in HER2-positive breast cancer patients using trastuzumab and its influencing factors at Iran Hospital.

Trastuzumab is primarily utilized in the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer. This study aimed to investigate the incidence of cardiac toxicity associated with trastuzumab in HER2-positive breast cancer patients at Iran Hospital in 2023, as well as the factors influencing this toxicity. In this cross-sectional study, 200 patients diagnosed with HER2-positive breast cancer and receiving trastuzumab were included.

Persistent Peril: Recurrent Deep Vein Thrombosis and Pulmonary Embolism in a Patient With Protein S Deficiency Despite Optimal Anticoagulation Therapies.

The clotting system has evolved as an adaptive mechanism to prevent blood loss during vascular damage. However, the intricate nature of the clotting cascade and the complexities of human life can sometimes lead to the unnatural activation of this delicate cascade. This can result in blood clot formation within the cardiovascular system, contributing to a wide range of pathological conditions.

Anti-N-Methyl-D-Aspartate Receptor Encephalopathy in a Young Female.

Widely distributed in the central nervous system (CNS), N-methyl-D-aspartate receptors (NMDARs) are believed to be involved in long-term potentiation, essential in regulating and forming memory. This condition primarily occurs in young females because of autoantibodies forming against the N-methyl-D-aspartate receptor-1 (NR1) or N-methyl-D-aspartate receptor-2 (NR2) subunits of NMDAR in the CNS, ultimately portraying a unique psychoneurological phenomenon. Patients with antibodies against NMDAR present with a combination of neurological and psychiatric signs and symptoms.

Designing, implementation and evaluation of story reading: a solution to increase general empathy in medical students.

Background: Communication and mutual understanding among healthcare providers is a significant concern within the healthcare system, and enhancing empathy is one way to foster effective communication and mutual understanding. The aim of this research is to evaluate and compare the impact of story reading on the level of empathy in medical students at Mazandaran University of Medical Sciences.

Methods: The study employed an intervention educational design (a quasi-experimental), with a convenience sample of 51 medical students selected as the statistical population.

Dental Infection Causing Methicillin-Resistant Staphylococcus aureus Bacteremia and Spinal Infection: A Case Report.

Poor dentition as a source of infection causing bacteremia and spinal infections (such as paraspinal abscess, and discitis) should be considered even in the absence of recent dental surgery. The case presents a patient found to have an infection in the cervical and thoracic spine, methicillin-resistant  bacteremia, and poor dentition. Although the patient had a history of drug use, he denied a history of intravenous drug use.

Takotsubo Cardiomyopathy Induced by Stress From Amyotrophic Lateral Sclerosis and a Mechanical Fall.

Named after the Japanese octopus trap, Takotsubo cardiomyopathy is an acute myocardial condition characterized by a reversible ventricular dysfunction with ballooning of the left ventricle (LV) during systole. A catecholamine surge is likely the primary mechanism responsible for myocardial damage in this condition. The association between amyotrophic lateral sclerosis (ALS) and Takotsubo cardiomyopathy has not been well established.

Enhancing residents' neonatal resuscitation competency through team-based simulation training: an intervention educational study.

Background: Neonatal resuscitation training in a simulated delivery room environment is a new paradigm in pediatric medical education. The purpose of this research is to highlight team-based simulation as an effective method of teaching neonatal resuscitation to senior pediatric residents.

Methods: In an intervention educational study, we evaluated the impact of team-based simulation training in the development of neonatal resuscitation.

CICIoT2023: A Real-Time Dataset and Benchmark for Large-Scale Attacks in IoT Environment.

Nowadays, the Internet of Things (IoT) concept plays a pivotal role in society and brings new capabilities to different industries. The number of IoT solutions in areas such as transportation and healthcare is increasing and new services are under development. In the last decade, society has experienced a drastic increase in IoT connections.

CapsRule: Explainable Deep Learning for Classifying Network Attacks.

Despite the potential deep learning (DL) algorithms have shown, their lack of transparency hinders their widespread application. Extracting if-then rules from deep neural networks is a powerful explanation method to capture nonlinear local behaviors. However, existing rule extraction methods suffer from inefficiency, incomprehensibility, infidelity, and not scaling well.

Liquefaction Potential of Saturated Sand Reinforced by Cement-Grouted Micropiles: An Evolutionary Approach Based on Shaking Table Tests.

Cement-grouted injections are increasingly employed as a countermeasure material against liquefaction in active seismic areas; however, there is no methodology to thoroughly and directly evaluate the liquefaction potential of saturated sand materials reinforced by the cement grout-injected micropiles. To this end, first, a series of 1 g shaking table model tests are conducted. Time histories of pore water pressures, excess pore water pressure ratios (r), and the number of required cycles (N) to liquefy the soil are obtained and modified lower and upper boundaries are suggested for the potential of liquefaction of both pure and grout-reinforced sand.

Perceived Challenges Caused by Covid-19 Outbreak in Students of Medical Sciences.

Background: Students of medical sciences are a highly vulnerable group during COVID-19 pandemic who may experience a wide range of challenges and stresses. The aim of this study was to investigate the perceived challenges caused by COVID-19 outbreak in students of medical sciences.

Materials And Methods: A qualitative study was carried out based on conventional qualitative content analysis following Graneheim and Lundman from December 2020 to February 2021.

The impact of intra-sacroiliac joint methylprednisolone injection in the recovery of patients with spondyloarthropathy: a randomized controlled trial.

Introduction: Spondyloarthropathies are a group of chronic inflammatory diseases with specific clinical symptoms in rheumatic diseases. These patients suffer from pain in the joints. Physicians have tried several ways to decrease the pain in these patients.

Desmopressin Acetate in Percutaneous Ultrasound-Guided Native Kidney Biopsy in Patients with Reduced Kidney Function: A Double-Blind Randomized Controlled Trial.

Introduction: Bleeding events are the most common complications after kidney biopsy. This study aims to evaluate the effect of desmopressin administration on bleeding complication, in native kidney biopsy candidates with reduced kidney function.

Methods: This double-blind randomized clinical trial enrolled 18 to 80 years old patients with 15 < eGFR < 90 mL/min/ 1.

Exploration the role of a clinical supervisor to improve the professional skills of medical students: a content analysis study.

Background And Purpose: Clinical supervision supports learners and paves the way for effective and efficient learning in clinical settings. This study aimed to explain the responsibilities of clinical supervisors in clinical education wards to improve the professional skills of medical students.

Materials And Methods: In this qualitative study, we used the conventional content analysis approach.

Towards the third generation universities: The core innovative function approach.

Undoubtedly, economic and social value added depends on the functions of universities. Moving toward third-generation universities (3rd GU) is an inevitable process. These universities need different functions than traditional ones; therefore, identifying and determining their functions is essential.

Vowel duration measurement in school-age children with cochlear implant.

Objectives: Normal hearing system is an essential factor for accurate production of speech segments. It seems that cochlear implant prosthesis helps children with hearing impairment to speak more accurately than before receiving prosthesis. The current research aimed to compare the vowel duration in school-aged children with cochlear implants and that in children with normal hearing.

Hy-Bridge: A Hybrid Blockchain for Privacy-Preserving and Trustful Energy Transactions in Internet-of-Things Platforms.

In the current centralized IoT ecosystems, all financial transactions are routed through IoT platform providers. The security and privacy issues are inevitable with an untrusted or compromised IoT platform provider. To address these issues, we propose Hy-Bridge, a hybrid blockchain-based billing and charging framework.

Structural Requirements of the Third-Generation University: The Case of Medical Sciences Universities in Iran.

Introduction: Given the social, economic, environmental and internal developments of universities, the necessity for medical universities to move to being third-generation universities has been demonstrated. These universities, along with the requirements of entrepreneurship and commercialization of research, are in need of structural requirements. This study was conducted with the aim to identify and introduce the structural requirements of medical sciences universities in Iran in the transition to the third-generation universities.

Prevention of Contrast-induced Nephropathy in Patients with Chronic Kidney Disease Undergoing Elective Coronary Angioplasty or Angiography with Sodium Potassium Citrate Solution, a Double Blind Randomized Clinical Trial.

Introduction: Contrast-induced nephropathy (CIN) is a frequent complication of contrast exposure. A recent study suggested that Na/K citrate might have a preventive role. We investigated the efficacy of Na/K citrate to prevent CIN in patients with renal dysfunction undergoing coronary intervention.

The relationship between comprehension of syntax and reading comprehension in cochlear implanted and hearing children.

Objectives: There is a large variation in the function of cochlear implanted children in language assessments. However, they usually have poorer performance in language abilities compared with their normal hearing peers. The purpose of the present study was to determine the relationship between syntax comprehension and reading comprehension in cochlear implanted and hearing children in the third to fifth grades of the elementary school and to identify the relationship between their reading comprehension and the age of receiving a cochlear implant as well as the duration of receiving speech therapy in cochlear implanted children.

Evaluating the Relationship Between Serum Level of Interleukin-6 and Rheumatoid Arthritis Severity and Disease Activity.

Aim: The aim of this study was to evaluate the relationship between Interleukin-6 (IL-6) serum level and the severity and activity of Rheumatoid Arthritis (RA).

Methods: In this cross-sectional study, 120 RA patients referred to the rheumatology clinic, the patients were diagnosed by rheumatologists according to ACR / EULAR 2010 criteria. Based on DAS28 score the patients were divided into 4 groups: Remission, Mild, Moderate and Severe.