An Updated Overview of Existing Cancer Databases and Identified Needs.

Our search of existing cancer databases aimed to assess the current landscape and identify key needs. We analyzed 71 databases, focusing on genomics, proteomics, lipidomics, and glycomics. We found a lack of cancer-related lipidomic and glycomic databases, indicating a need for further development in these areas.

Comprehensive and User-Analytics-Friendly Cancer Patient Database for Physicians and Researchers.

Nuanced cancer patient care is needed, as the development and clinical course of cancer is multifactorial with influences from the general health status of the patient, germline and neoplastic mutations, co-morbidities, and environment. To effectively tailor an individualized treatment to each patient, such multifactorial data must be presented to providers in an easy-to-access and easy-to-analyze fashion. To address the need, a relational database has been developed integrating status of cancer-critical gene mutations, serum galectin profiles, serum and tumor glycomic profiles, with clinical, demographic, and lifestyle data points of individual cancer patients.

Malachite Green, the hazardous materials that can bind to Apo-transferrin and change the iron transfer.

Different groups of synthetic dyes might lead to environmental pollution. The binding affinity among hazardous materials with biomolecules necessitates a detailed understanding of their binding properties. Malachite Green might induce a change in the iron transfer by Apo-transferrin.

Development of a highly sensitive and selective mercury optical sensor based on immobilization of bis(thiophenal)-4,4'-methylenedianiline on a PVC membrane.

A reversible optical sensor was fabricated for highly sensitive and selective determination of Hg(II) ions. The optode was prepared using a newly synthesized ionophore, bis(thiophenal)-4,4'-methylenedianiline, and ETH-5294 as a lipophilic H(+)-selective indicator in a plasticized PVC membrane. Different variables affect the optical signal such as pH and compositions of the membrane components were optimized.

Development of a specific and highly sensitive optical chemical sensor for determination of Hg(II) based on a new synthesized ionophore.

A novel optode for determination of Hg(II) ions is developed based on immobilization of a recently synthesized ionophore, 7-(1H-imidazol-1-ylmethyl)-5,6,7,8,9,10-hexahydro-2H-1,13,4,7,10 benzodioxatriaza cyclopentadecine-3,11(4H,12H)-dione, in a PVC membrane. Dioctyl sebacate was used as a plasticizer, sodium tetraphenylborate as an anionic additive and ETH5294 as a chromoionophore. The response of the optode was based on the complexation of Hg(II) with the ionophore in the membrane phase, resulting an ion exchange process between Hg(II) in the sample solution and H(+) in the membrane.

A highly sensitive and selective bulk optode based on benzimidazol derivative as an ionophore and ETH5294 for the determination of ultra trace amount of silver ions.

A novel optical chemical sensor (optode) was fabricated for the determination of silver ions. The optical sensor was prepared by incorporating recently synthesized ionophore, 7-(1H-benzimidazol-1-ylmethyl)-5,6,7,8,9,10-hexahydro-2H-1,13,4,7,10-benzodioxatriaza cyclopentadecine-3,11(4H,12H)-dione, sodium tetraphenyl borate (NaTPB) as an anionic additive, 3-octadecanoylimino-7-(diethylamino)-1,2-benzophenoxazine (ETH5294) as a chromoionophore, and dioctyl phthalate (DOP) as a plasticizer in a poly(vinyl chloride) membrane. The effect of several parameters in determining Ag(+) was studied and optimized.

An optical chemical sensor for mercury ion based on 2-mercaptopyrimidine in PVC membrane.

An optical chemical sensor based on 2-mercaptopyrimidine (2-MP) in plasticized poly(vinyl chloride) (PVC) membrane incorporating (N,N-diethyl-5-(octadecanoylimino)-5H benzo[a]phenoxazine-9-amine (ETH 5294) and sodium tetraphenyl borate (NaTPB) for batch and flow-through determination of mercury ion is described. The response of the sensor is based on selective complexation of Hg(2+) with 2-MP in the membrane phase, resulting in an ion exchange process between H(+) in the membrane and Hg(2+) in the sample solution. The influences of several experimental parameters, such as membrane composition, pH, and type and concentration of the regenerating reagent, were investigated.