Publications by authors named "Ali Dbouk"
Article Synopsis
- - The study investigates the prevalence of inherited cancer susceptibility variants in patients with pancreatic cancer and nonpancreatic periampullary cancers, emphasizing that both groups show similar rates of these variants.
- - A total of 608 patients were analyzed, revealing that 7.7% carried significant germline variants, with 89% linked to major cancer susceptibility genes and a notable majority having a family cancer history.
- - The findings support the recommendation for germline susceptibility testing in all patients with periampullary cancers, not just those with pancreatic cancer.
Article Synopsis
- The study explores how levels of the carbohydrate antigen CA19-9 and a related glycan, DUPAN-2, can aid in diagnosing pancreatic cancer, particularly highlighting differences based on genetic variants in fucosyltransferase (FUT) enzymes.
- It involved analyzing genetic data from 938 individuals to determine how these variants affect serum levels of DUPAN-2 and CA19-9, with findings suggesting improved diagnostic sensitivity for early-stage pancreatic cancer.
- The conclusion emphasizes the potential of combining genetic testing with tumor markers to enhance diagnostic accuracy for pancreatic cancer, showing promising results when using a combination of FUT, CA19-9, and DUPAN-2 tests.
C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) and early T2DM. C-peptide protects endothelial cells by activating AMP-activated protein kinase α, thus suppressing the activity of NAD(P)H oxidase activity and reducing reactive oxygen species (ROS) generation.
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- The study investigates how regular use of proton pump inhibitors (PPIs) impacts the microbiomes of pancreatic and duodenal tissues, especially in relation to pancreatic cancer risk.
- It analyzes microbiome profiles from 103 patients, revealing that PPI users have a significantly altered duodenal microbiome, with notable enrichment of Firmicutes and Streptococcus species.
- The research highlights differences in microbiome diversity between the pancreas head and body/tail, finding that PPI use is linked to changes in both duodenal and pancreatic tissue microbiome profiles, although more pronounced effects were noted in the duodenum.
Purpose: CA19-9 synthesis is influenced by common variants in the fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect FUT variants, and evaluated its diagnostic performance for pancreatic ductal adenocarcinoma (PDAC).
Experimental Design: A representative set of controls from the Cancer of the Pancreas Screening study was identified for each FUT functional group.