Anti-glioblastoma effects of nanomicelle-curcumin plus erlotinib.

Glioblastoma (GBM), one of the most significant brain neoplasms, is characterized by high metastasis and recurrence. Crossing the blood-brain barrier is one of the main therapeutic obstacles, seriously hampering therapeutic agents entering the brain. This research investigated the co-delivery of erlotinib and curcumin nanomicelles for enhancing anti-GBM treatment .

Combination Therapy with Nanomicellar-Curcumin and Temozolomide for In Vitro Therapy of Glioblastoma Multiforme via Wnt Signaling Pathways.

Glioblastoma (GBM) is the most serious brain tumor and shows a high rate of drug resistance. Wnt signaling is a very important pathway in GBM that can activate/inhibit other pathways, such as apoptosis and autophagy. In this study, we evaluated the efficacy of a combination of temozolomide (TMZ) plus curcumin or nanomicellar-curcumin on the inhibition of GBM growth in vitro, via effects on autophagy, apoptosis, and the Wnt signaling pathway.

Mineral Trioxide Aggregate Partial Pulpotomy Versus Formocresol Pulpotomy: A Randomized, Split-Mouth, Controlled Clinical Trial with 24 Months Follow-Up.

Purpose: The purpose of this study was to evaluate the clinical and radiographic success rates of mineral trioxide aggregate partial pulpotomy (PP) compared to formocresol pulpotomy (FP) in human primary molars.

Methods: In this randomized, controlled, split-mouth, clinical trial, 25 healthy five- to eight-year-olds, with 50 carious primary mandibular second molars lacking clinical and radiographic evidence of pulp pathology, were selected. The selected teeth were randomly assigned into two groups, PP and FP, for vital pulp therapy.

Glass ionomer cements as fissure sealing materials: yes or no?: A systematic review and meta-analysis.

Background: The aim of this systematic review and meta-analysis was to evaluate the ability of glass ionomer cements (GICs) and resin-based sealants (RBSs) to prevent the occurrence of caries and their retention in standards-based clinical studies.

Types Of Studies Reviewed: The authors conducted a literature search (from database inception through September 20, 2017) to identify studies for inclusion in this systematic review. The authors assessed the quality of the evidence with the modified Jadad scale and performed the meta-analysis by using a random-effects model.

Microbial microleakage assessment of class V cavities restored with different materials and techniques: A laboratory study.

Background: The aim of this study was to compare microbial microleakage of class V cavities restored with different materials and techniques using a microbial leakage assessment method.

Materials And Methods: One hundred extracted, caries-free, human maxillary premolars were randomly divided into five groups. Group 1: Resin-modified glass ionomer (RMGI), Group 2: Closed sandwich with flowable composite + nanohybrid composite, Group 3: Nanohybrid composite, Group 4: Closed sandwich with RMGI + nanohybrid composite, and Group 5: Flowable composite + nanohybrid composite that were co-cured together ("snow-plow" technique).

Can tert-butylhydroquinone improve the healing of extracted tooth socket in rats?

Background: Tooth extraction causes an open wound in the soft and hard tissues. During the inflammatory phase of the healing process, a large amount of free radicals are produced and cause oxidative stress, which leads to tissue damage and delayed wound healing. Thus, in this study, we evaluated the effect of tert-butylhydroquinone (TBHQ), as an antioxidant, on the healing process of tooth sockets in rats.

Preparation before acid etching in fissure sealant therapy: yes or no?: A systematic review and meta-analysis.

Background: The authors of this systematic review and meta-analysis had 2 aims: to evaluate fissure sealant retention with and without the use of a preparation method and to compare fissure sealant retention using the preparation-only method before sealant placement with the conventional acid-etching procedure.

Types Of Studies Reviewed: The authors conducted a literature search (from database inception through June 2, 2016) to identify studies for inclusion in this systematic review. The authors assessed the quality of the evidence with the modified Jadad scale and performed the meta-analysis by using a random-effects model.

Children's behavioral pain reactions during local anesthetic injection using cotton-roll vibration method compared with routine topical anesthesia: A randomized controlled trial.

Background: Topical anesthesia has been widely advocated as an important component of atraumatic administration of intraoral local anesthesia. The aim of this study was to use direct observation of children's behavioral pain reactions during local anesthetic injection using cotton-roll vibration method compared with routine topical anesthesia.

Materials And Methods: Forty-eight children participated in this randomized controlled clinical trial.

Adhesive systems under fissure sealants: yes or no?: A systematic review and meta-analysis.

Background: The authors of this systematic review and meta-analysis had 2 aims: to evaluate fissure sealant retention with and without the use of an adhesive system and to compare fissure sealant retention using etch-and-rinse adhesive systems versus self-etching adhesive systems.

Types Of Studies Reviewed: The authors conducted a literature search (all articles published through November 1, 2015) to identify studies for inclusion in this systematic review. They assessed the quality of the evidence provided using the modified Jadad scale and performed meta-analyses using a random-effects model.

Phylogenetic Analysis of Selected Menthol-Producing Species Belonging to the Lamiaceae Family.

Menthol is an organic compound with diverse medicinal and commercial applications, and is made either synthetically or through extraction from mint oils. The aim of the present study was to investigate menthol levels in selected menthol-producing species belonging to the Lamiaceae family, and to determine phylogenetic relationships of menthol dehydrogenase gene sequence among these species. Three genus of Lamiaceae, namely Mentha, Salvia, and Micromeria, were selected for phytochemical and phylogenetic analyses.

Microbial microleakage assessment of a new hydrophilic fissure sealant: a laboratory study.

Purpose: The purpose of this study was to compare microbial leakage of a new hydrophilic sealant with that of a conventional hydrophobic resin-based sealant.

Methods: One hundred extracted, caries-free, human maxillary premolars were randomly divided into five groups. Those in Groups 1, 2, and 3 had dry, wet, and artificial saliva-contaminated occlusal surfaces, respectively, and were sealed with a hydrophilic sealant, while those in Groups 4 and 5 had dry and wet occlusal surfaces, respectively, and were sealed with a hydrophobic sealant.

Microleakage assessment of fissure sealant following fissurotomy bur or pumice prophylaxis use before etching.

Background: A prolonged life of fissure sealant has always been the target for preventing caries in vulnerable newly erupted teeth. The use of preparatory techniques including bur introduction to the fissures is considered among such improving steps.

Materials And Methods: Ninety freshly extracted healthy maxillary premolar teeth were randomly selected for this investigation.

Association between dental caries and age-specific body mass index in preschool children of an Iranian population.

Background: The aim of this study was to determine the association of dental caries and BMI-for-age in preschool children and whether BMI-for-age is similar or different between Severe Early Childhood Caries (S-ECC) and caries free children.

Materials And Methods: Four hundred preschool children aged 30-70 months were entered into this study. The parameters examined in this study were weight, height, BMI-for-age and number of decayed, extracted and filled surfaces of deciduous teeth (defs).

Comparison of some salivary characteristics between children with and without early childhood caries.

Background And Aim: Early childhood caries (ECC) is one of the most common chronic childhood diseases. Saliva as a host factor plays an essential role in maintaining the integrity of oral structures. The aim of the present study was to compare resting salivary pH, buffering capacity, and secretory immunoglobulin A (sIgA), calcium, and phosphate concentrations between children with and without ECC.

Is there an association between early childhood caries and serum iron and serum ferritin levels?

Background: Early childhood caries (ECC) is a virulent form of dental caries that can destroy the primary dentition of preschool children. The purpose of this study was to investigate a possible association between ECC with serum iron and serum ferritin levels.

Materials And Methods: Following the ethical approval, 204 children aged 24-71 months were recruited for a double-blind, randomized cross-sectional study.

Assessment of dental maturity of children aged 3.5 to 13.5 years using the Demirjian method in an Iranian population.

Radiographs of developing teeth are commonly used to assess dental maturity. The method for assessment of dental maturity first described by Demirjian is widely used and accepted. The aim of this study was to assess the accuracy of the Demirjian method in an Iranian population in order to compare the difference in dental maturity between these children with the data obtained in Canadian children and to determine whether there is a correlation between dental maturity and BMI-for-age.

An in vitro study of root and canal morphology of human deciduous molars in an Iranian population.

Dental caries is the most common chronic childhood disease. Deep caries and dental trauma are the two main etiologic factors responsible for pulp involvement. Better knowledge of the morphology of the root canals of deciduous teeth can improve the outcome of pulp treatment.

Comparison of the salivary immunoglobulin concentration levels between children with early childhood caries and caries-free children.

Background: Early Childhood Caries (ECC) is one of the most common chronic childhood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few industrialized nations. Saliva as a host factor can play an important role in the process of dental caries.