Multimorbidity in neurodegenerative diseases: a network analysis.

The socioeconomic costs of neurodegenerative diseases (NDs) are highly affected by comorbidities. This study aims to enhance our understanding of the prevalent complications of NDs through the lens of network analysis. A multimorbidity network (MN) was constructed based on a longitudinal EHR dataset of 93,647,498 diagnoses of 824,847 patients.

Survival, mortality and epidemic risk status of COVID-19: a population-based Study in Golestan province, Iran.

Background: Appreciating the various dimensions of the coronavirus disease 2019 (COVID-19) pandemic can improve health systems and prepare them to deal better with future pandemics and public health events. This study was conducted to investigate the association between the survival of hospitalized patients with COVID-19 and the epidemic risk stratification of the disease in Golestan province, Iran.

Methods: In this study, all patients with COVID-19 who were hospitalized in the hospitals of Golestan province of Iran from February 20, 2020, to December 19, 2022, and were registered in the Medical Care Monitoring Center (MCMC) system (85,885 individuals) were examined.

OSABSS: An authentic examination for assessing basic surgical skills in surgical residents.

Objectives: This study aimed to develop and validate the OSABSS (Objective Structured Assessment of Basic Surgical Skills), a modified Objective Structured Clinical Examination (OSCE), to assess basic surgical skills in residents.

Design: A developmental study conducted in two phases. Basic skills were identified through literature review and gap analysis.

Incidence Rates and Time Trends of Skin Cancer in Golestan Province, Northeastern Iran, 2005-2018.

Background: Given the significant occurrence of skin cancer in the Middle East and the existing research gap concerning its incidence and trends, this research aimed to study the epidemiology and trend changes of skin cancer in the Golestan province, Northeastern Iran.

Methods: The Golestan Population-based Cancer Registry's (GPCR's) data bank was utilized to gather information on confirmed skin cancer cases in the province during 2005-2018. We used Poisson regression analysis for comparing incidence rates between groups.

Primary Biliary Tract Cancers in Golestan, Iran: 13-Year Experience of Golestan Population-Based Cancer Registry.

Background: Epidemiological research on the high-risk population might be helpful in early detection and prevention of biliary tract malignancies. This study assesses the prevalence of biliary tract cancer (BTC) in the Golestan province, northeastern Iran, between 2004 and 2016.

Methods: The current study used information from the Golestan Population-based Cancer Registry (GPCR) to access the epidemiology of BTC across a 13-year period while taking into account temporal and geographic differences.

Therapeutic and prophylactic effects of radiation therapy in the management of recurrent granulation tissue induced tracheal stenosis: a review on the role of Endobronchial brachytherapy and external beam radiation therapy.

Purpose: Granulation tissue-induced tracheal stenosis (mainly secondary to intubation or lung transplantation) is one of the most common etiologies of benign airway obstructions. Recurrence rates after standard treatment options (surgical resection and/or endobronchial interventions) can inadvertently worsen the stricture through the stimulation of more granulation tissue generation (via increased fibroblast activity and roliferation). Low-dose radiotherapy could be a promising tool to prevent granulation tissue formation after surgery and/or endobronchial interventions regarding its established role in the treatment of keloids or hypertrophic scars, two benign diseases with similar a pathophysiology to tracheal stenosis.

Universal Langmuir and Fractal Analysis of High-Resolution Adsorption Isotherms of Argon and Nitrogen on Macroporous Silica.

High-resolution isotherms of argon and nitrogen adsorption on macroporous silica have been simulated with universal Langmuir and fractal models. A four-parameter, fractal universal Langmuir equation is a good fit to the data at low pressures. Standard Gibbs energy changes calculated from equilibrium adsorption coefficients show a series of broad peaks that indicate adsorbate structural transformations as a function of pressure and coverage.

Dated Phylogeny of Section (Fabaceae) and Allied Taxa in the Hypoglottis Clade.

The subgenus Bunge, which consists of several sections, is one of the taxonomically most complicated groups in the genus. The section Bunge belongs to this subgenus and is a significant element of the Irano-Turanian floristic region. A molecular phylogenetic analysis of this section and its closely related taxa using nuclear ribosomal DNA internal transcribed spacers (ITS) and external transcribed spacer (ETS) regions as well as plastid K sequences were conducted.

Predictors of poor cosmesis in breast cancer patients treated with adjuvant whole breast radiation therapy plus high-dose-rate interstitial brachytherapy boost after breast conservation surgery.

Purpose: To identify patient, tumor, and treatment-related factors, which predict cosmesis in breast cancer survivors treated with adjuvant whole breast irradiation (WBI) plus high-dose-rate (HDR) multicatheter interstitial brachytherapy (MIBT) boost after breast conservation surgery.

Material And Methods: At least 12 months after completion of radiotherapy, cosmetic outcomes were measured both objectively with BCCT.core software (using a front view digital photograph), and subjectively according to Harvard's criteria.

, , and Wound Healing Activity of Willd.

Methods: The methanolic root extract was prepared by maceration, and flavonoids were evaluated by LC/MS. examination was performed based on the LC/MS results, and the binding affinity of these compounds to estrogen receptors (ERs) and was evaluated. Wound healing evaluation in both (NHDF cell line, by 500 g/ml concentration of the extract, 24 h) and (Wistar rat, topical daily treated with 1.

The comparison of transforming growth factor beta-1 serum levels in early-stage breast cancer patients treated with external beam whole breast irradiation plus boost versus interstitial brachytherapy accelerated partial breast irradiation.

Purpose: Transforming growth factor beta-1 (TGF-β1) is a profibrotic cytokine used as an early biomarker to develop radiation-induced fibrosis (RIF). This study aimed to compare TGF-β1 serum levels in early-stage breast cancer patients treated with whole-breast radiation therapy (WBRT) plus boost versus accelerated partial breast irradiation (APBI) using multicatheter interstitial brachytherapy.

Methods And Materials: This clinical trial study was conducted on 20 women with early-stage breast cancer after breast-conserving surgery candidate for adjuvant radiotherapy in Golestan hospital, Ahvaz, in 2021.

The Design of an Audit Test for Co Brachytherapy Treatment Planning System.

Background: Auditing the treatment planning system (TPS) software for a radiotherapy unit is of paramount importance in any radiation therapy department. A Plexiglas phantom was proposed to measure the ionization of Co high dose rate (HDR) source and compare dose points in the planning system for auditing and verifying TPS.

Methods: Auditing was performed using a Plexiglas phantom in an end-to-end test, and relative dose points were detected by a farmer-type ionization chamber and compared with the relative dose of similar points in TPS.

In Vitro and In Vivo Wound Healing Activity of Boiss. (Fabaceae).

Estrogens are a group of sex hormones which have receptors on the skin and lead to increased cells and wound healing. Normally isoflavonoids are present in Boiss. (Leguminosae).

Variations in Structure among Androecia and Floral Nectaries in the Inverted Repeat-Lacking Clade ().

The vast majority of highly valuable species of the Leguminosae in temperate latitudes belong to the Inverted Repeat-Lacking Clade (IRLC). Despite having a generally conserved monosymmetric floral morphology, members of this group are remarkable with a pronounced diversity of floral sizes, modes of staminal fusion, and pollination strategies. This paper examined androecia and floral nectaries (FNs) in selected genera of the IRLC.

Genome Size and Chromosome Number Evaluation of L. sect. Bunge (Fabaceae).

section is one of the important characteristic elements of thorn-cushion formations in the Irano-Turanian floristic region. In this paper, we examined the chromosome number of 17 species (15 new reports) and provide estimates of genome size for 62 individuals belonging to 38 taxa of sect. , some species outside this section, plus two species.

Role of non-absorbable oral antibiotics in bowel preparation for intracavitary brachytherapy: effects of rifaximin on rectal dosimetric parameters during vaginal cuff brachytherapy.

Purpose: Brachytherapy is a major tool for dose escalation in gynecological cancer treatment. Control of rectal repletion is particularly challenging; it can impact dose received by this organ at risk and there are reported toxicities. The use of methods, such as enema and bowel preparation, to reduce rectal volume is a difficult process for patients, and its repeatability requires patients' cooperation.

Impact of radiobiological models on the calculation of the therapeutic parameters of Grid therapy for breast cancer.

Therapeutic advantages of Grid therapy have been demonstrated in several theoretical studies using the standard linear-quadratic (LQ) model. However, the suitability of the LQ model when describing cell killing at highly modulated radiation fields has been questioned. In this study, we have applied an extended LQ model to recalculate therapeutic parameters of Grid therapy.

Trend and epidemiological patterns of animal bites in Golestan province (Northern Iran) between 2017 and 2020.

Background: Rabies is one of the oldest zoonosis viral diseases, which still remains as one of the most important threats to public health in the 21st century.

Methods: This cross-sectional study examined epidemiologic features of all 33,996 cases of persons bitten by animals and referred to the rabies prophylaxis centers in Golestan province between March 2017 and March 2020. Factors included demographic information of the victim (age, gender, and occupation), type of invasive animals (dog, cat, and other types), time of bite (year, month, and hour), place of residence (urban or rural), and injury and treatment statuses.

Effect of Printing Parameters on Dimensional Error, Surface Roughness and Porosity of FFF Printed Parts with Grid Structure.

Extrusion printing processes allow for manufacturing complex shapes in a relatively cheap way with low-cost machines. The present study analyzes the effect of printing parameters on dimensional error, roughness, and porosity of printed PLA parts obtained with grid structure. Parts are obtained by means of the fused filament fabrication (FFF) process.

Reversible Deactivation Radical Polymerization: From Polymer Network Synthesis to 3D Printing.

3D printing has changed the fabrication of advanced materials as it can provide customized and on-demand 3D networks. However, 3D printing of polymer materials with the capacity to be transformed after printing remains a great challenge for engineers, material, and polymer scientists. Radical polymerization has been conventionally used in photopolymerization-based 3D printing, as in the broader context of crosslinked polymer networks.

Ocular muscle metastasis as the initial presentation of a malignant pheochromocytoma: A unique case.

In this paper, we discuss a unique manifestation of malignant pheochromocytoma, which presented with ocular pain. The histopathological study pointed to a possible pheochromocytoma origin. Subsequently, the patient underwent thorough imaging and paraclinical evaluations, which confirmed the diagnosis of pheochromocytoma.

Evaluation of rectal volume correlation with dosimetric parameters during optimized intracavitary high-dose-rate brachytherapy in cervical cancer.

Purpose: Brachytherapy (BRT) is a cornerstone in cervical cancer treatment, with the ultimate goal to maximize the tumor dose while sparing organs at risk (OARs), such as rectum. Several studies evaluated the effect of rectal volume on rectal doses, but the results are inconsistent. This study aimed to evaluate the rectal volume and dose-volume histogram (DVH) relationship in high-dose-rate (HDR) brachytherapy in locally advanced cervical cancer.

Anterior Column Realignment: Analysis of Neurological Risk and Radiographic Outcomes.

Background: Anterior column realignment (ACR) is a less invasive alternative to 3-column osteotomy for the correction of sagittal imbalance. We hypothesized that ACR would correct sagittal imbalance with an acceptable neurological risk.

Objective: To assess long-term neurological and radiographic outcomes after ACR.

Dosimetric analysis of breast cancer tumor bed boost: An interstitial brachytherapy vs. external beam radiation therapy comparison for deeply seated tumors.

Purpose: To dosimetrically compare interstitial brachytherapy (MIBT) vs. EBRT (3DCRT and high-energy electron beams) for deep-seated tumor bed boosts (depth ≥4 cm) in early-stage breast cancer.

Methods And Materials: Planning CTs of fifteen left-side breast cancer patients previously treated with MIBT boost chosen for this study.

A Versatile 3D and 4D Printing System through Photocontrolled RAFT Polymerization.

Reversible addition-fragmentation chain-transfer (RAFT) polymerization is a valuable tool for synthesizing macromolecules with controlled topologies and diverse chemical functionalities. However, the application of RAFT polymerization to additive-manufacturing processes has been prevented due to the slow polymerization rates of typical systems. In this work, we developed and optimized a rapid visible (green) light mediated RAFT polymerization process and applied it to an open-air 3D printing system.