The effect of medial prefrontal cortex electrical stimulation on passive avoidance memory in healthy and addict rats.

Background: The medial prefrontal cortex (mPFC) is a part of brain reward system involved in cognitive functions such as learning and memory. The mPFC receives strong dopaminergic innervations from ventral tegmental area (VTA) that comprises a portion of the mesolimbic dopaminergic system (MLDS), and sends glutamatergic projections to both the VTA and nucleus accumbens (NAc).

Materials And Methods: In this study, male Wister rats weighing 250-350 g were used.